Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2017.10.031
Title: Dual modal ultra-bright nanodots with aggregation-induced emission and gadolinium-chelation for vascular integrity and leakage detection
Authors: Feng, Guangxue 
Li, Jackson Liang Yao
Claser, Carla
Balachander, Akhila
Tan, Yingrou
Goh, Chi Ching 
Kwok, Immanuel Weng Han
Renia, Laurent 
Tang, Ben Zhong
Ng, Lai Guan 
Liu, Bin 
Keywords: Science & Technology
Technology
Engineering, Biomedical
Materials Science, Biomaterials
Engineering
Materials Science
Inflammation imaging
Aggregation-induced emission
Blood brain barrier integrity
Two-photon fluorescence imaging
Vascular imaging
BLOOD-BRAIN-BARRIER
ULTRABRIGHT ORGANIC DOTS
SINGLE-CELL RESOLUTION
EVANS BLUE
IN-VIVO
PERMEABILITY
FLUORESCENCE
TRACKING
Issue Date: 1-Jan-2018
Publisher: ELSEVIER
Citation: Feng, Guangxue, Li, Jackson Liang Yao, Claser, Carla, Balachander, Akhila, Tan, Yingrou, Goh, Chi Ching, Kwok, Immanuel Weng Han, Renia, Laurent, Tang, Ben Zhong, Ng, Lai Guan, Liu, Bin (2018-01-01). Dual modal ultra-bright nanodots with aggregation-induced emission and gadolinium-chelation for vascular integrity and leakage detection. BIOMATERIALS 152 : 77-85. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2017.10.031
Abstract: © 2017 The study of blood brain barrier (BBB) functions is important for neurological disorder research. However, the lack of suitable tools and methods has hampered the progress of this field. Herein, we present a hybrid nanodot strategy, termed AIE-Gd dots, comprising of a fluorogen with aggregation-induced emission (AIE) characteristics as the core to provide bright and stable fluorescence for optical imaging, and gadolinium (Gd) for accurate quantification of vascular leakage via inductively-coupled plasma mass spectrometry (ICP-MS). In this report, we demonstrate that AIE-Gd dots enable direct visualization of brain vascular networks under resting condition, and that they form localized punctate aggregates and accumulate in the brain tissue during experimental cerebral malaria, indicative of hemorrhage and BBB malfunction. With its superior detection sensitivity and multimodality, we hereby propose that AIE-Gd dots can serve as a better alternative to Evans blue for visualization and quantification of changes in brain barrier functions.
Source Title: BIOMATERIALS
URI: https://scholarbank.nus.edu.sg/handle/10635/169841
ISSN: 01429612
18785905
DOI: 10.1016/j.biomaterials.2017.10.031
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