Please use this identifier to cite or link to this item: https://doi.org/10.3390/nu11030660
Title: U-Shaped Relationship between Serum Leptin Concentration and Cognitive Performance in Older Asian Adults
Authors: Annweiler, Cedric
Duval, Guillaume T
Cheng, Ching-Yu 
Wong, Tien-Yin 
Lamoureux, Ecosse L 
Milea, Dan 
Sabanayagam, Charumathi 
Keywords: Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
leptin
cognition
older adults
PLASMA LEPTIN
EYE DISEASES
RISK-FACTOR
DEMENTIA
METHODOLOGY
VALIDITY
HORMONE
OBESITY
Issue Date: 19-Mar-2019
Publisher: MDPI
Citation: Annweiler, Cedric, Duval, Guillaume T, Cheng, Ching-Yu, Wong, Tien-Yin, Lamoureux, Ecosse L, Milea, Dan, Sabanayagam, Charumathi (2019-03-19). U-Shaped Relationship between Serum Leptin Concentration and Cognitive Performance in Older Asian Adults. NUTRIENTS 11 (3). ScholarBank@NUS Repository. https://doi.org/10.3390/nu11030660
Abstract: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. The role of leptin (a hormone related to fat mass) in cognition remains equivocal. Our objective was to investigate the relationship between circulating leptin concentration and cognition in older adults, accounting for potential confounders. We categorized 1061 community-dwelling older participants ≥60 years (mean ± SD, 70.6 ± 6.4 years; 41.6% female) from the Singapore Kidney Eye Study according to quintiles of leptin concentration (≤2.64; 2.64–5.1; 5.2–8.6; 8.7–17.96; ≥18 ng/mL). Cognition was assessed using the total and domain scores of the Abbreviated Mental Test (AMT). Age, gender, body mass index, mean arterial pressure, smoking, alcohol, education, memory complaint, anxiodepressive disorders, circulating concentrations of 25-hydroxyvitamin D, glycosylated hemoglobin, low-density lipoprotein cholesterol, and estimated glomerular filtration rate were used as potential confounders. Participants within the lowest (Q1) and highest (Q5) leptin quintiles exhibited lower (i.e., worse) mean total AMT scores compared to those within the intermediate quintiles (Q2, Q3, and Q4). Compared to Q3 as the reference, Q1 and Q5 were associated with decreased total AMT score (respectively, β = −0.53 p = 0.018; β = −0.60 p = 0.036). Compared to Q3, Q5 was also associated with decreased subscores on anterograde (β = −0.19 p = 0.020) and retrograde episodic memories (β = −0.18 p = 0.039). We found a non-linear U-shaped relationship between circulating leptin and cognition, with both lower and higher concentrations of leptin being associated with more severe cognitive impairment in community-dwelling older Asians.
Source Title: NUTRIENTS
URI: https://scholarbank.nus.edu.sg/handle/10635/169200
ISSN: 2072-6643
DOI: 10.3390/nu11030660
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