Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0209517
Title: N-Terminal pro C-Type Natriuretic Peptide (NTproCNP) and myocardial function in ageing
Authors: Keng B.M.H.
Gao F. 
Tan R.S. 
Ewe S.H. 
Teo L.L.Y.
Xie B.Q.
Goh G.B.B. 
Koh W.-P. 
Koh A.S. 
Keywords: biological marker
natriuretic peptide type C
biological marker
natriuretic peptide type C
age
aged
aging
amino terminal sequence
Article
clinical evaluation
clinical indicator
cohort analysis
diagnostic test accuracy study
diastolic dysfunction
female
functional assessment
heart atrium contraction
heart function
heart muscle relaxation
high risk population
human
major clinical study
male
myocardial disease
prospective study
risk assessment
sensitivity and specificity
sex difference
aging
blood
blood flow velocity
cardiac muscle
cardiovascular disease
diastole
geriatrics
inflammation
pathology
pathophysiology
physiology
Aged
Aging
Biomarkers
Blood Flow Velocity
Cardiovascular Diseases
Diastole
Female
Geriatrics
Humans
Inflammation
Male
Myocardium
Natriuretic Peptide, C-Type
Issue Date: 2018
Publisher: Public Library of Science
Citation: Keng B.M.H., Gao F., Tan R.S., Ewe S.H., Teo L.L.Y., Xie B.Q., Goh G.B.B., Koh W.-P., Koh A.S. (2018). N-Terminal pro C-Type Natriuretic Peptide (NTproCNP) and myocardial function in ageing. PLoS ONE 13 (12) : e0209517. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0209517
Abstract: Ageing-related alterations in cardiovascular structure and function are commonly associated with chronic inflammation. A potential blood-based biomarker indicative of a chronic inflammatory state is N-Terminal Pro C-Type Natriuretic Peptide (NTproCNP). We aim to investigate associations between NTproCNP and ageing-related impairments in cardiovascular function. Community-based participants underwent same-day assessment of cardiovascular function and circulating profiles of plasma NTproCNP. Associations between cardiovascular and biomarker profiles were studied in adjusted models including standard covariates. We studied 93 participants (mean age 73 ± 5.3 years, 36 women), of whom 55 (59%) had impaired myocardial relaxation (ratio of peak velocity flow in early diastole E (m/ s) to peak velocity flow in late diastole by atrial contraction A (m/s) <0.84). Participants with impaired myocardial relaxation were also found to have lower peak early phase filling velocity (0.6 ± 0.1 vs 0.7 ± 0.1, p < 0.0001) and higher peak atrial phase filling velocity (0.9 ± 0.1 vs 0.7 ± 0.1, p < 0.0001). NTproCNP levelswere significantly lower among participants with impaired myocardial relaxation (16.4% vs 39.5% with NTproCNP 19, p = 0.012). After multivariable adjustments, NTproCNP was independently associated with impaired myocardial relaxation (OR 2.99, 95%CI 1.12–8.01, p = 0.029). Community elderly adults with myocardial ageing have lower NTproCNP levels compared to those with preserved myocardial function. Given that impaired myocardial relaxation probably represents early changes within the myocardium with ageing, NTproCNP may be useful as an ‘upstream’ biomarker useful for charting myocardial ageing. © 2018 Keng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/165890
ISSN: 19326203
DOI: 10.1371/journal.pone.0209517
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1371_journal_pone_0209517.pdf517.98 kBAdobe PDF

OPEN

NoneView/Download

Page view(s)

48
checked on Oct 30, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.