Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0209517
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dc.titleN-Terminal pro C-Type Natriuretic Peptide (NTproCNP) and myocardial function in ageing
dc.contributor.authorKeng B.M.H.
dc.contributor.authorGao F.
dc.contributor.authorTan R.S.
dc.contributor.authorEwe S.H.
dc.contributor.authorTeo L.L.Y.
dc.contributor.authorXie B.Q.
dc.contributor.authorGoh G.B.B.
dc.contributor.authorKoh W.-P.
dc.contributor.authorKoh A.S.
dc.date.accessioned2020-03-23T06:18:14Z
dc.date.available2020-03-23T06:18:14Z
dc.date.issued2018
dc.identifier.citationKeng B.M.H., Gao F., Tan R.S., Ewe S.H., Teo L.L.Y., Xie B.Q., Goh G.B.B., Koh W.-P., Koh A.S. (2018). N-Terminal pro C-Type Natriuretic Peptide (NTproCNP) and myocardial function in ageing. PLoS ONE 13 (12) : e0209517. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0209517
dc.identifier.issn19326203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/165890
dc.description.abstractAgeing-related alterations in cardiovascular structure and function are commonly associated with chronic inflammation. A potential blood-based biomarker indicative of a chronic inflammatory state is N-Terminal Pro C-Type Natriuretic Peptide (NTproCNP). We aim to investigate associations between NTproCNP and ageing-related impairments in cardiovascular function. Community-based participants underwent same-day assessment of cardiovascular function and circulating profiles of plasma NTproCNP. Associations between cardiovascular and biomarker profiles were studied in adjusted models including standard covariates. We studied 93 participants (mean age 73 ± 5.3 years, 36 women), of whom 55 (59%) had impaired myocardial relaxation (ratio of peak velocity flow in early diastole E (m/ s) to peak velocity flow in late diastole by atrial contraction A (m/s) <0.84). Participants with impaired myocardial relaxation were also found to have lower peak early phase filling velocity (0.6 ± 0.1 vs 0.7 ± 0.1, p < 0.0001) and higher peak atrial phase filling velocity (0.9 ± 0.1 vs 0.7 ± 0.1, p < 0.0001). NTproCNP levelswere significantly lower among participants with impaired myocardial relaxation (16.4% vs 39.5% with NTproCNP 19, p = 0.012). After multivariable adjustments, NTproCNP was independently associated with impaired myocardial relaxation (OR 2.99, 95%CI 1.12–8.01, p = 0.029). Community elderly adults with myocardial ageing have lower NTproCNP levels compared to those with preserved myocardial function. Given that impaired myocardial relaxation probably represents early changes within the myocardium with ageing, NTproCNP may be useful as an ‘upstream’ biomarker useful for charting myocardial ageing. © 2018 Keng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.publisherPublic Library of Science
dc.sourceUnpaywall 20200320
dc.subjectbiological marker
dc.subjectnatriuretic peptide type C
dc.subjectbiological marker
dc.subjectnatriuretic peptide type C
dc.subjectage
dc.subjectaged
dc.subjectaging
dc.subjectamino terminal sequence
dc.subjectArticle
dc.subjectclinical evaluation
dc.subjectclinical indicator
dc.subjectcohort analysis
dc.subjectdiagnostic test accuracy study
dc.subjectdiastolic dysfunction
dc.subjectfemale
dc.subjectfunctional assessment
dc.subjectheart atrium contraction
dc.subjectheart function
dc.subjectheart muscle relaxation
dc.subjecthigh risk population
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmyocardial disease
dc.subjectprospective study
dc.subjectrisk assessment
dc.subjectsensitivity and specificity
dc.subjectsex difference
dc.subjectaging
dc.subjectblood
dc.subjectblood flow velocity
dc.subjectcardiac muscle
dc.subjectcardiovascular disease
dc.subjectdiastole
dc.subjectgeriatrics
dc.subjectinflammation
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectAged
dc.subjectAging
dc.subjectBiomarkers
dc.subjectBlood Flow Velocity
dc.subjectCardiovascular Diseases
dc.subjectDiastole
dc.subjectFemale
dc.subjectGeriatrics
dc.subjectHumans
dc.subjectInflammation
dc.subjectMale
dc.subjectMyocardium
dc.subjectNatriuretic Peptide, C-Type
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.description.doi10.1371/journal.pone.0209517
dc.description.sourcetitlePLoS ONE
dc.description.volume13
dc.description.issue12
dc.description.pagee0209517
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