Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0209517
DC Field | Value | |
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dc.title | N-Terminal pro C-Type Natriuretic Peptide (NTproCNP) and myocardial function in ageing | |
dc.contributor.author | Keng B.M.H. | |
dc.contributor.author | Gao F. | |
dc.contributor.author | Tan R.S. | |
dc.contributor.author | Ewe S.H. | |
dc.contributor.author | Teo L.L.Y. | |
dc.contributor.author | Xie B.Q. | |
dc.contributor.author | Goh G.B.B. | |
dc.contributor.author | Koh W.-P. | |
dc.contributor.author | Koh A.S. | |
dc.date.accessioned | 2020-03-23T06:18:14Z | |
dc.date.available | 2020-03-23T06:18:14Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Keng B.M.H., Gao F., Tan R.S., Ewe S.H., Teo L.L.Y., Xie B.Q., Goh G.B.B., Koh W.-P., Koh A.S. (2018). N-Terminal pro C-Type Natriuretic Peptide (NTproCNP) and myocardial function in ageing. PLoS ONE 13 (12) : e0209517. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0209517 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/165890 | |
dc.description.abstract | Ageing-related alterations in cardiovascular structure and function are commonly associated with chronic inflammation. A potential blood-based biomarker indicative of a chronic inflammatory state is N-Terminal Pro C-Type Natriuretic Peptide (NTproCNP). We aim to investigate associations between NTproCNP and ageing-related impairments in cardiovascular function. Community-based participants underwent same-day assessment of cardiovascular function and circulating profiles of plasma NTproCNP. Associations between cardiovascular and biomarker profiles were studied in adjusted models including standard covariates. We studied 93 participants (mean age 73 ± 5.3 years, 36 women), of whom 55 (59%) had impaired myocardial relaxation (ratio of peak velocity flow in early diastole E (m/ s) to peak velocity flow in late diastole by atrial contraction A (m/s) <0.84). Participants with impaired myocardial relaxation were also found to have lower peak early phase filling velocity (0.6 ± 0.1 vs 0.7 ± 0.1, p < 0.0001) and higher peak atrial phase filling velocity (0.9 ± 0.1 vs 0.7 ± 0.1, p < 0.0001). NTproCNP levelswere significantly lower among participants with impaired myocardial relaxation (16.4% vs 39.5% with NTproCNP 19, p = 0.012). After multivariable adjustments, NTproCNP was independently associated with impaired myocardial relaxation (OR 2.99, 95%CI 1.12–8.01, p = 0.029). Community elderly adults with myocardial ageing have lower NTproCNP levels compared to those with preserved myocardial function. Given that impaired myocardial relaxation probably represents early changes within the myocardium with ageing, NTproCNP may be useful as an ‘upstream’ biomarker useful for charting myocardial ageing. © 2018 Keng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.publisher | Public Library of Science | |
dc.source | Unpaywall 20200320 | |
dc.subject | biological marker | |
dc.subject | natriuretic peptide type C | |
dc.subject | biological marker | |
dc.subject | natriuretic peptide type C | |
dc.subject | age | |
dc.subject | aged | |
dc.subject | aging | |
dc.subject | amino terminal sequence | |
dc.subject | Article | |
dc.subject | clinical evaluation | |
dc.subject | clinical indicator | |
dc.subject | cohort analysis | |
dc.subject | diagnostic test accuracy study | |
dc.subject | diastolic dysfunction | |
dc.subject | female | |
dc.subject | functional assessment | |
dc.subject | heart atrium contraction | |
dc.subject | heart function | |
dc.subject | heart muscle relaxation | |
dc.subject | high risk population | |
dc.subject | human | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | myocardial disease | |
dc.subject | prospective study | |
dc.subject | risk assessment | |
dc.subject | sensitivity and specificity | |
dc.subject | sex difference | |
dc.subject | aging | |
dc.subject | blood | |
dc.subject | blood flow velocity | |
dc.subject | cardiac muscle | |
dc.subject | cardiovascular disease | |
dc.subject | diastole | |
dc.subject | geriatrics | |
dc.subject | inflammation | |
dc.subject | pathology | |
dc.subject | pathophysiology | |
dc.subject | physiology | |
dc.subject | Aged | |
dc.subject | Aging | |
dc.subject | Biomarkers | |
dc.subject | Blood Flow Velocity | |
dc.subject | Cardiovascular Diseases | |
dc.subject | Diastole | |
dc.subject | Female | |
dc.subject | Geriatrics | |
dc.subject | Humans | |
dc.subject | Inflammation | |
dc.subject | Male | |
dc.subject | Myocardium | |
dc.subject | Natriuretic Peptide, C-Type | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) | |
dc.description.doi | 10.1371/journal.pone.0209517 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 13 | |
dc.description.issue | 12 | |
dc.description.page | e0209517 | |
Appears in Collections: | Elements Staff Publications |
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