Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep43832
Title: Pupillary responses to short-wavelength light are preserved in aging
Authors: RUKMINI, AV 
MILEA, DAN 
AUNG, TIN 
GOOLEY, JOSHUA J 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
RETINAL GANGLION-CELLS
AGE-RELATED-CHANGES
MELATONIN SUPPRESSION
BLUE-LIGHT
CATARACT-SURGERY
BRIGHT LIGHT
MONOCHROMATIC LIGHT
FLICKER PHOTOMETRY
INTRAOCULAR-LENSES
PHOTIC HISTORY
Issue Date: 7-Mar-2017
Publisher: NATURE PUBLISHING GROUP
Citation: RUKMINI, AV, MILEA, DAN, AUNG, TIN, GOOLEY, JOSHUA J (2017-03-07). Pupillary responses to short-wavelength light are preserved in aging. SCIENTIFIC REPORTS 7 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/srep43832
Abstract: © 2017 The Author(s). With aging, less blue light reaches the retina due to gradual yellowing of the lens. This could result in reduced activation of blue light-sensitive melanopsin-containing retinal ganglion cells, which mediate non-visual light responses (e.g., the pupillary light reflex, melatonin suppression, and circadian resetting). Herein, we tested the hypothesis that older individuals show greater impairment of pupillary responses to blue light relative to red light. Dose-response curves for pupillary constriction to 469-nm blue light and 631-nm red light were compared between young normal adults aged 21-30 years (n = 60) and older adults aged ≥50 years (normal, n = 54; mild cataract, n = 107; severe cataract, n = 18). Irrespective of wavelength, pupillary responses were reduced in older individuals and further attenuated by severe, but not mild, cataract. The reduction in pupillary responses was comparable in response to blue light and red light, suggesting that lens yellowing did not selectively reduce melanopsin-dependent light responses. Compensatory mechanisms likely occur in aging that ensure relative constancy of pupillary responses to blue light despite changes in lens transmission.
Source Title: SCIENTIFIC REPORTS
URI: https://scholarbank.nus.edu.sg/handle/10635/155340
ISSN: 20452322
DOI: 10.1038/srep43832
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