Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep43832
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dc.titlePupillary responses to short-wavelength light are preserved in aging
dc.contributor.authorRUKMINI, AV
dc.contributor.authorMILEA, DAN
dc.contributor.authorAUNG, TIN
dc.contributor.authorGOOLEY, JOSHUA J
dc.date.accessioned2019-06-07T01:53:04Z
dc.date.available2019-06-07T01:53:04Z
dc.date.issued2017-03-07
dc.identifier.citationRUKMINI, AV, MILEA, DAN, AUNG, TIN, GOOLEY, JOSHUA J (2017-03-07). Pupillary responses to short-wavelength light are preserved in aging. SCIENTIFIC REPORTS 7 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/srep43832
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/155340
dc.description.abstract© 2017 The Author(s). With aging, less blue light reaches the retina due to gradual yellowing of the lens. This could result in reduced activation of blue light-sensitive melanopsin-containing retinal ganglion cells, which mediate non-visual light responses (e.g., the pupillary light reflex, melatonin suppression, and circadian resetting). Herein, we tested the hypothesis that older individuals show greater impairment of pupillary responses to blue light relative to red light. Dose-response curves for pupillary constriction to 469-nm blue light and 631-nm red light were compared between young normal adults aged 21-30 years (n = 60) and older adults aged ≥50 years (normal, n = 54; mild cataract, n = 107; severe cataract, n = 18). Irrespective of wavelength, pupillary responses were reduced in older individuals and further attenuated by severe, but not mild, cataract. The reduction in pupillary responses was comparable in response to blue light and red light, suggesting that lens yellowing did not selectively reduce melanopsin-dependent light responses. Compensatory mechanisms likely occur in aging that ensure relative constancy of pupillary responses to blue light despite changes in lens transmission.
dc.language.isoen
dc.publisherNATURE PUBLISHING GROUP
dc.sourceElements
dc.subjectScience & Technology
dc.subjectMultidisciplinary Sciences
dc.subjectScience & Technology - Other Topics
dc.subjectRETINAL GANGLION-CELLS
dc.subjectAGE-RELATED-CHANGES
dc.subjectMELATONIN SUPPRESSION
dc.subjectBLUE-LIGHT
dc.subjectCATARACT-SURGERY
dc.subjectBRIGHT LIGHT
dc.subjectMONOCHROMATIC LIGHT
dc.subjectFLICKER PHOTOMETRY
dc.subjectINTRAOCULAR-LENSES
dc.subjectPHOTIC HISTORY
dc.typeArticle
dc.date.updated2019-06-03T22:48:59Z
dc.contributor.departmentOPHTHALMOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/srep43832
dc.description.sourcetitleSCIENTIFIC REPORTS
dc.description.volume7
dc.description.issue1
dc.published.statePublished
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