Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.canlet.2008.06.015
| Title: | Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC | Authors: | Matsuda, D. Khoo, S.K. Massie, A. Iwamura, M. Chen, J. Petillo, D. Wondergem, B. Avallone, M. Kloostra, S.J. Tan, M.-H. Koeman, J. Zhang, Z. Kahnoski, R.J. Baba, S. Teh, B.T. |
Keywords: | Beta-induced gene Clear cell RCC Copy number alterations Papillary RCC Pathological features Transforming growth factor |
Issue Date: | 18-Dec-2008 | Citation: | Matsuda, D., Khoo, S.K., Massie, A., Iwamura, M., Chen, J., Petillo, D., Wondergem, B., Avallone, M., Kloostra, S.J., Tan, M.-H., Koeman, J., Zhang, Z., Kahnoski, R.J., Baba, S., Teh, B.T. (2008-12-18). Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC. Cancer Letters 272 (2) : 260-267. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2008.06.015 | Abstract: | We report and characterize the copy number alterations (CNAs) in 35 clear cell and 12 papillary renal cell carcinomas (RCC) using Affymetrix 100K SNP arrays. Novel gain and loss regions are identified in both subtypes. In addition, statistically significant CNA are detected and associated with the pathological features: VHL mutation status, tumor grades, and sarcomatoid component in clear cell RCC and in types 1 and 2 of papillary RCC. Florescence in situ hybridization confirmed the copy number gain in the transforming growth factor, beta-induced gene (TGFBI), which is a possible oncogene for clear cell RCC. © 2008 Elsevier Ireland Ltd. All rights reserved. | Source Title: | Cancer Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/130871 | ISSN: | 03043835 | DOI: | 10.1016/j.canlet.2008.06.015 |
| Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
SCOPUSTM
Citations
21
checked on Jan 12, 2021
WEB OF SCIENCETM
Citations
20
checked on Jan 12, 2021
Page view(s)
65
checked on Jan 2, 2021
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.