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Title: Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC
Authors: Matsuda, D.
Khoo, S.K.
Massie, A.
Iwamura, M.
Chen, J.
Petillo, D.
Wondergem, B.
Avallone, M.
Kloostra, S.J.
Tan, M.-H. 
Koeman, J.
Zhang, Z.
Kahnoski, R.J.
Baba, S.
Teh, B.T. 
Keywords: Beta-induced gene
Clear cell RCC
Copy number alterations
Papillary RCC
Pathological features
Transforming growth factor
Issue Date: 18-Dec-2008
Citation: Matsuda, D., Khoo, S.K., Massie, A., Iwamura, M., Chen, J., Petillo, D., Wondergem, B., Avallone, M., Kloostra, S.J., Tan, M.-H., Koeman, J., Zhang, Z., Kahnoski, R.J., Baba, S., Teh, B.T. (2008-12-18). Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC. Cancer Letters 272 (2) : 260-267. ScholarBank@NUS Repository.
Abstract: We report and characterize the copy number alterations (CNAs) in 35 clear cell and 12 papillary renal cell carcinomas (RCC) using Affymetrix 100K SNP arrays. Novel gain and loss regions are identified in both subtypes. In addition, statistically significant CNA are detected and associated with the pathological features: VHL mutation status, tumor grades, and sarcomatoid component in clear cell RCC and in types 1 and 2 of papillary RCC. Florescence in situ hybridization confirmed the copy number gain in the transforming growth factor, beta-induced gene (TGFBI), which is a possible oncogene for clear cell RCC. © 2008 Elsevier Ireland Ltd. All rights reserved.
Source Title: Cancer Letters
ISSN: 03043835
DOI: 10.1016/j.canlet.2008.06.015
Appears in Collections:Staff Publications

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