Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2008.06.015
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dc.titleIdentification of copy number alterations and its association with pathological features in clear cell and papillary RCC
dc.contributor.authorMatsuda, D.
dc.contributor.authorKhoo, S.K.
dc.contributor.authorMassie, A.
dc.contributor.authorIwamura, M.
dc.contributor.authorChen, J.
dc.contributor.authorPetillo, D.
dc.contributor.authorWondergem, B.
dc.contributor.authorAvallone, M.
dc.contributor.authorKloostra, S.J.
dc.contributor.authorTan, M.-H.
dc.contributor.authorKoeman, J.
dc.contributor.authorZhang, Z.
dc.contributor.authorKahnoski, R.J.
dc.contributor.authorBaba, S.
dc.contributor.authorTeh, B.T.
dc.date.accessioned2016-11-28T10:13:38Z
dc.date.available2016-11-28T10:13:38Z
dc.date.issued2008-12-18
dc.identifier.citationMatsuda, D., Khoo, S.K., Massie, A., Iwamura, M., Chen, J., Petillo, D., Wondergem, B., Avallone, M., Kloostra, S.J., Tan, M.-H., Koeman, J., Zhang, Z., Kahnoski, R.J., Baba, S., Teh, B.T. (2008-12-18). Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC. Cancer Letters 272 (2) : 260-267. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2008.06.015
dc.identifier.issn03043835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/130871
dc.description.abstractWe report and characterize the copy number alterations (CNAs) in 35 clear cell and 12 papillary renal cell carcinomas (RCC) using Affymetrix 100K SNP arrays. Novel gain and loss regions are identified in both subtypes. In addition, statistically significant CNA are detected and associated with the pathological features: VHL mutation status, tumor grades, and sarcomatoid component in clear cell RCC and in types 1 and 2 of papillary RCC. Florescence in situ hybridization confirmed the copy number gain in the transforming growth factor, beta-induced gene (TGFBI), which is a possible oncogene for clear cell RCC. © 2008 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.canlet.2008.06.015
dc.sourceScopus
dc.subjectBeta-induced gene
dc.subjectClear cell RCC
dc.subjectCopy number alterations
dc.subjectPapillary RCC
dc.subjectPathological features
dc.subjectTransforming growth factor
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1016/j.canlet.2008.06.015
dc.description.sourcetitleCancer Letters
dc.description.volume272
dc.description.issue2
dc.description.page260-267
dc.description.codenCALED
dc.identifier.isiut000261755900010
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