Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2008.06.015
Title: Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC
Authors: Matsuda, D.
Khoo, S.K.
Massie, A.
Iwamura, M.
Chen, J.
Petillo, D.
Wondergem, B.
Avallone, M.
Kloostra, S.J.
Tan, M.-H. 
Koeman, J.
Zhang, Z.
Kahnoski, R.J.
Baba, S.
Teh, B.T. 
Keywords: Beta-induced gene
Clear cell RCC
Copy number alterations
Papillary RCC
Pathological features
Transforming growth factor
Issue Date: 18-Dec-2008
Citation: Matsuda, D., Khoo, S.K., Massie, A., Iwamura, M., Chen, J., Petillo, D., Wondergem, B., Avallone, M., Kloostra, S.J., Tan, M.-H., Koeman, J., Zhang, Z., Kahnoski, R.J., Baba, S., Teh, B.T. (2008-12-18). Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC. Cancer Letters 272 (2) : 260-267. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2008.06.015
Abstract: We report and characterize the copy number alterations (CNAs) in 35 clear cell and 12 papillary renal cell carcinomas (RCC) using Affymetrix 100K SNP arrays. Novel gain and loss regions are identified in both subtypes. In addition, statistically significant CNA are detected and associated with the pathological features: VHL mutation status, tumor grades, and sarcomatoid component in clear cell RCC and in types 1 and 2 of papillary RCC. Florescence in situ hybridization confirmed the copy number gain in the transforming growth factor, beta-induced gene (TGFBI), which is a possible oncogene for clear cell RCC. © 2008 Elsevier Ireland Ltd. All rights reserved.
Source Title: Cancer Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/130871
ISSN: 03043835
DOI: 10.1016/j.canlet.2008.06.015
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

18
checked on Jul 16, 2018

WEB OF SCIENCETM
Citations

17
checked on Jun 20, 2018

Page view(s)

14
checked on Apr 19, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.