Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling

Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201300683

Title:	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling
Authors:	Li, Z. Hao, P. Li, L. Tan, C.Y.J. Cheng, X. Chen, G.Y.J. Sze, S.K. Shen, H.-M. Yao, S.Q.
Keywords:	affinity-based probes fluorescent probes kinases photo-crosslinking proteomics
Issue Date:	12-Aug-2013
Citation:	Li, Z., Hao, P., Li, L., Tan, C.Y.J., Cheng, X., Chen, G.Y.J., Sze, S.K., Shen, H.-M., Yao, S.Q. (2013-08-12). Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angewandte Chemie - International Edition 52 (33) : 8551-8556. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201300683
Abstract:	Less is more: A minimalist "clickable" photo-crosslinker (see scheme) was incorporated with numerous small-molecule kinase inhibitors. The resulting probes were used for both in vitro (cell lysates) and in situ (live cells) proteome profiling, for large-scale identification of their potential cellular kinase targets and shows improved outcomes over previous probes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title:	Angewandte Chemie - International Edition
URI:	http://scholarbank.nus.edu.sg/handle/10635/75868
ISSN:	14337851
DOI:	10.1002/anie.201300683
Appears in Collections:	Staff Publications

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