Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201300683
Title: Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling
Authors: Li, Z.
Hao, P.
Li, L. 
Tan, C.Y.J.
Cheng, X.
Chen, G.Y.J. 
Sze, S.K.
Shen, H.-M. 
Yao, S.Q. 
Keywords: affinity-based probes
fluorescent probes
kinases
photo-crosslinking
proteomics
Issue Date: 12-Aug-2013
Citation: Li, Z., Hao, P., Li, L., Tan, C.Y.J., Cheng, X., Chen, G.Y.J., Sze, S.K., Shen, H.-M., Yao, S.Q. (2013-08-12). Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angewandte Chemie - International Edition 52 (33) : 8551-8556. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201300683
Abstract: Less is more: A minimalist "clickable" photo-crosslinker (see scheme) was incorporated with numerous small-molecule kinase inhibitors. The resulting probes were used for both in vitro (cell lysates) and in situ (live cells) proteome profiling, for large-scale identification of their potential cellular kinase targets and shows improved outcomes over previous probes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Angewandte Chemie - International Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/75868
ISSN: 14337851
DOI: 10.1002/anie.201300683
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

88
checked on Oct 16, 2018

WEB OF SCIENCETM
Citations

86
checked on Oct 8, 2018

Page view(s)

85
checked on Aug 3, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.