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|Title:||Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling|
|Citation:||Li, Z., Hao, P., Li, L., Tan, C.Y.J., Cheng, X., Chen, G.Y.J., Sze, S.K., Shen, H.-M., Yao, S.Q. (2013-08-12). Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angewandte Chemie - International Edition 52 (33) : 8551-8556. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201300683|
|Abstract:||Less is more: A minimalist "clickable" photo-crosslinker (see scheme) was incorporated with numerous small-molecule kinase inhibitors. The resulting probes were used for both in vitro (cell lysates) and in situ (live cells) proteome profiling, for large-scale identification of their potential cellular kinase targets and shows improved outcomes over previous probes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Source Title:||Angewandte Chemie - International Edition|
|Appears in Collections:||Staff Publications|
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