Please use this identifier to cite or link to this item:
https://doi.org/10.1117/1.3183811
Title: | Fibro-C-Index: Comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy | Authors: | Tai, D.C.S. Tan, N. Xu, S. Kang, C.H. Chia, S.M. Cheng, C.L. Wee, A. Wei, C.L. Raja, A.M. Xiao, G. Chang, S. Rajapakse, J.C. So, P.T.C. Tang, H.-H. Chen, C.S. Yu, H. |
Keywords: | bioimaging diagnosis liver fibrosis medical optics second harmonic generation two photon |
Issue Date: | 2009 | Citation: | Tai, D.C.S., Tan, N., Xu, S., Kang, C.H., Chia, S.M., Cheng, C.L., Wee, A., Wei, C.L., Raja, A.M., Xiao, G., Chang, S., Rajapakse, J.C., So, P.T.C., Tang, H.-H., Chen, C.S., Yu, H. (2009). Fibro-C-Index: Comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy. Journal of Biomedical Optics 14 (4) : -. ScholarBank@NUS Repository. https://doi.org/10.1117/1.3183811 | Abstract: | We develop a standardized, fully automated, quantification system for liver fibrosis assessment using second harmonic generation microscopy and a morphology-based quantification algorithm. Liver fibrosis is associated with an abnormal increase in collagen as a result of chronic liver diseases. Histopathological scoring is the most commonly used method for liver fibrosis assessment, where a liver biopsy is stained and scored by experienced pathologists. Due to the intrinsic limited sensitivity and operator-dependent variations, there exist high inter- and intraobserver discrepancies. We validate our quantification system, Fibro-C-Index, with a comprehensive animal study and demonstrate its potential application in clinical diagnosis to reduce inter- and intraobserver discrepancies. © 2009 Society of Photo-Optical Instrumentation Engineers. | Source Title: | Journal of Biomedical Optics | URI: | http://scholarbank.nus.edu.sg/handle/10635/53435 | ISSN: | 10833668 | DOI: | 10.1117/1.3183811 |
Appears in Collections: | Staff Publications |
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