Please use this identifier to cite or link to this item: https://doi.org/10.1117/1.3183811
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dc.titleFibro-C-Index: Comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy
dc.contributor.authorTai, D.C.S.
dc.contributor.authorTan, N.
dc.contributor.authorXu, S.
dc.contributor.authorKang, C.H.
dc.contributor.authorChia, S.M.
dc.contributor.authorCheng, C.L.
dc.contributor.authorWee, A.
dc.contributor.authorWei, C.L.
dc.contributor.authorRaja, A.M.
dc.contributor.authorXiao, G.
dc.contributor.authorChang, S.
dc.contributor.authorRajapakse, J.C.
dc.contributor.authorSo, P.T.C.
dc.contributor.authorTang, H.-H.
dc.contributor.authorChen, C.S.
dc.contributor.authorYu, H.
dc.date.accessioned2014-05-20T02:29:25Z
dc.date.available2014-05-20T02:29:25Z
dc.date.issued2009
dc.identifier.citationTai, D.C.S., Tan, N., Xu, S., Kang, C.H., Chia, S.M., Cheng, C.L., Wee, A., Wei, C.L., Raja, A.M., Xiao, G., Chang, S., Rajapakse, J.C., So, P.T.C., Tang, H.-H., Chen, C.S., Yu, H. (2009). Fibro-C-Index: Comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy. Journal of Biomedical Optics 14 (4) : -. ScholarBank@NUS Repository. https://doi.org/10.1117/1.3183811
dc.identifier.issn10833668
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/53435
dc.description.abstractWe develop a standardized, fully automated, quantification system for liver fibrosis assessment using second harmonic generation microscopy and a morphology-based quantification algorithm. Liver fibrosis is associated with an abnormal increase in collagen as a result of chronic liver diseases. Histopathological scoring is the most commonly used method for liver fibrosis assessment, where a liver biopsy is stained and scored by experienced pathologists. Due to the intrinsic limited sensitivity and operator-dependent variations, there exist high inter- and intraobserver discrepancies. We validate our quantification system, Fibro-C-Index, with a comprehensive animal study and demonstrate its potential application in clinical diagnosis to reduce inter- and intraobserver discrepancies. © 2009 Society of Photo-Optical Instrumentation Engineers.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1117/1.3183811
dc.sourceScopus
dc.subjectbioimaging
dc.subjectdiagnosis
dc.subjectliver fibrosis
dc.subjectmedical optics
dc.subjectsecond harmonic generation
dc.subjecttwo photon
dc.typeArticle
dc.contributor.departmentSINGAPORE-MIT ALLIANCE
dc.contributor.departmentNATIONAL UNIVERSITY MEDICAL INSTITUTES
dc.description.doi10.1117/1.3183811
dc.description.sourcetitleJournal of Biomedical Optics
dc.description.volume14
dc.description.issue4
dc.description.page-
dc.description.codenJBOPF
dc.identifier.isiut000270540100020
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