Please use this identifier to cite or link to this item:
https://doi.org/10.1117/1.3183811
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dc.title | Fibro-C-Index: Comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy | |
dc.contributor.author | Tai, D.C.S. | |
dc.contributor.author | Tan, N. | |
dc.contributor.author | Xu, S. | |
dc.contributor.author | Kang, C.H. | |
dc.contributor.author | Chia, S.M. | |
dc.contributor.author | Cheng, C.L. | |
dc.contributor.author | Wee, A. | |
dc.contributor.author | Wei, C.L. | |
dc.contributor.author | Raja, A.M. | |
dc.contributor.author | Xiao, G. | |
dc.contributor.author | Chang, S. | |
dc.contributor.author | Rajapakse, J.C. | |
dc.contributor.author | So, P.T.C. | |
dc.contributor.author | Tang, H.-H. | |
dc.contributor.author | Chen, C.S. | |
dc.contributor.author | Yu, H. | |
dc.date.accessioned | 2014-05-20T02:29:25Z | |
dc.date.available | 2014-05-20T02:29:25Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Tai, D.C.S., Tan, N., Xu, S., Kang, C.H., Chia, S.M., Cheng, C.L., Wee, A., Wei, C.L., Raja, A.M., Xiao, G., Chang, S., Rajapakse, J.C., So, P.T.C., Tang, H.-H., Chen, C.S., Yu, H. (2009). Fibro-C-Index: Comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy. Journal of Biomedical Optics 14 (4) : -. ScholarBank@NUS Repository. https://doi.org/10.1117/1.3183811 | |
dc.identifier.issn | 10833668 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/53435 | |
dc.description.abstract | We develop a standardized, fully automated, quantification system for liver fibrosis assessment using second harmonic generation microscopy and a morphology-based quantification algorithm. Liver fibrosis is associated with an abnormal increase in collagen as a result of chronic liver diseases. Histopathological scoring is the most commonly used method for liver fibrosis assessment, where a liver biopsy is stained and scored by experienced pathologists. Due to the intrinsic limited sensitivity and operator-dependent variations, there exist high inter- and intraobserver discrepancies. We validate our quantification system, Fibro-C-Index, with a comprehensive animal study and demonstrate its potential application in clinical diagnosis to reduce inter- and intraobserver discrepancies. © 2009 Society of Photo-Optical Instrumentation Engineers. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1117/1.3183811 | |
dc.source | Scopus | |
dc.subject | bioimaging | |
dc.subject | diagnosis | |
dc.subject | liver fibrosis | |
dc.subject | medical optics | |
dc.subject | second harmonic generation | |
dc.subject | two photon | |
dc.type | Article | |
dc.contributor.department | SINGAPORE-MIT ALLIANCE | |
dc.contributor.department | NATIONAL UNIVERSITY MEDICAL INSTITUTES | |
dc.description.doi | 10.1117/1.3183811 | |
dc.description.sourcetitle | Journal of Biomedical Optics | |
dc.description.volume | 14 | |
dc.description.issue | 4 | |
dc.description.page | - | |
dc.description.coden | JBOPF | |
dc.identifier.isiut | 000270540100020 | |
Appears in Collections: | Staff Publications |
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