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https://doi.org/10.1093/nar/gkn259
| Title: | pFlexAna: detecting conformational changes in remotely related proteins. | Authors: | Nigham, A. Tucker-Kellogg, L. Mihalek, I. Verma, C. Hsu, D. |
Issue Date: | 2008 | Citation: | Nigham, A., Tucker-Kellogg, L., Mihalek, I., Verma, C., Hsu, D. (2008). pFlexAna: detecting conformational changes in remotely related proteins.. Nucleic acids research 36 (Web Server issue) : W246-251. ScholarBank@NUS Repository. https://doi.org/10.1093/nar/gkn259 | Abstract: | The pFlexAna (protein flexibility analyzer) web server detects and displays conformational changes in remotely related proteins, without relying on sequence homology. To do so, it first applies a reliable statistical test to align core protein fragments that are structurally similar and then clusters these aligned fragment pairs into 'super-alignments', according to the similarity of geometric transformations that align them. The result is that the dominant conformational changes occur between the clusters, while the smaller conformational changes occur within a cluster. pFlexAna is available at http://bigbird.comp.nus.edu.sg/pfa2/. | Source Title: | Nucleic acids research | URI: | http://scholarbank.nus.edu.sg/handle/10635/43089 | ISSN: | 13624962 | DOI: | 10.1093/nar/gkn259 |
| Appears in Collections: | Staff Publications |
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