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|Title:||pFlexAna: detecting conformational changes in remotely related proteins.|
|Source:||Nigham, A., Tucker-Kellogg, L., Mihalek, I., Verma, C., Hsu, D. (2008). pFlexAna: detecting conformational changes in remotely related proteins.. Nucleic acids research 36 (Web Server issue) : W246-251. ScholarBank@NUS Repository. https://doi.org/10.1093/nar/gkn259|
|Abstract:||The pFlexAna (protein flexibility analyzer) web server detects and displays conformational changes in remotely related proteins, without relying on sequence homology. To do so, it first applies a reliable statistical test to align core protein fragments that are structurally similar and then clusters these aligned fragment pairs into 'super-alignments', according to the similarity of geometric transformations that align them. The result is that the dominant conformational changes occur between the clusters, while the smaller conformational changes occur within a cluster. pFlexAna is available at http://bigbird.comp.nus.edu.sg/pfa2/.|
|Source Title:||Nucleic acids research|
|Appears in Collections:||Staff Publications|
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