Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2003.12.024
Title: Photoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells
Authors: Du, H.Y.
Bay, B.H. 
Olivo, M.
Tan, B.K.H. 
Keywords: Confocal microscopy
Glutathione S-transferase
Nasopharyngeal carcinoma
Photodynamic therapy
Reactive oxygen species
Issue Date: 2004
Citation: Du, H.Y., Bay, B.H., Olivo, M., Tan, B.K.H. (2004). Photoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells. Cancer Letters 207 (2) : 175-181. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2003.12.024
Abstract: Photodynamic therapy (PDT) is a new modality of treatment for cancer. Hypericin is a photosensitizer, which is known to generate reactive oxygen species upon activation with light. We observed that photoactivated hypericin induces the generation of reactive oxygen intermediates in nasopharyngeal cancer (NPC) cells in vitro. There was also significant reduction of Glutathione S-transferase (GST) activity in HK1 and CNE-2 NPC cells and in tumor tissues from the NPC/HK1 murine tumor model by hypericin-mediated PDT. As antioxidants protect cells against phototoxicity, down-regulation of GST activity would potentiate the efficacy of hypericin-PDT treatment. © 2004 Elsevier Ireland Ltd. All rights reserved.
Source Title: Cancer Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/33872
ISSN: 03043835
DOI: 10.1016/j.canlet.2003.12.024
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