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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2003.12.024
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dc.titlePhotoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells
dc.contributor.authorDu, H.Y.
dc.contributor.authorBay, B.H.
dc.contributor.authorOlivo, M.
dc.contributor.authorTan, B.K.H.
dc.date.accessioned2012-06-08T09:30:27Z
dc.date.available2012-06-08T09:30:27Z
dc.date.issued2004
dc.identifier.citationDu, H.Y., Bay, B.H., Olivo, M., Tan, B.K.H. (2004). Photoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells. Cancer Letters 207 (2) : 175-181. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2003.12.024
dc.identifier.issn03043835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/33872
dc.description.abstractPhotodynamic therapy (PDT) is a new modality of treatment for cancer. Hypericin is a photosensitizer, which is known to generate reactive oxygen species upon activation with light. We observed that photoactivated hypericin induces the generation of reactive oxygen intermediates in nasopharyngeal cancer (NPC) cells in vitro. There was also significant reduction of Glutathione S-transferase (GST) activity in HK1 and CNE-2 NPC cells and in tumor tissues from the NPC/HK1 murine tumor model by hypericin-mediated PDT. As antioxidants protect cells against phototoxicity, down-regulation of GST activity would potentiate the efficacy of hypericin-PDT treatment. © 2004 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.canlet.2003.12.024
dc.sourceScopus
dc.subjectConfocal microscopy
dc.subjectGlutathione S-transferase
dc.subjectNasopharyngeal carcinoma
dc.subjectPhotodynamic therapy
dc.subjectReactive oxygen species
dc.typeArticle
dc.contributor.departmentANATOMY
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.canlet.2003.12.024
dc.description.sourcetitleCancer Letters
dc.description.volume207
dc.description.issue2
dc.description.page175-181
dc.description.codenCALED
dc.identifier.isiut000221074400006
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