Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2003.12.024
Title: Photoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells
Authors: Du, H.Y.
Bay, B.H. 
Olivo, M.
Tan, B.K.H. 
Keywords: Confocal microscopy
Glutathione S-transferase
Nasopharyngeal carcinoma
Photodynamic therapy
Reactive oxygen species
Issue Date: 2004
Source: Du, H.Y., Bay, B.H., Olivo, M., Tan, B.K.H. (2004). Photoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells. Cancer Letters 207 (2) : 175-181. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2003.12.024
Abstract: Photodynamic therapy (PDT) is a new modality of treatment for cancer. Hypericin is a photosensitizer, which is known to generate reactive oxygen species upon activation with light. We observed that photoactivated hypericin induces the generation of reactive oxygen intermediates in nasopharyngeal cancer (NPC) cells in vitro. There was also significant reduction of Glutathione S-transferase (GST) activity in HK1 and CNE-2 NPC cells and in tumor tissues from the NPC/HK1 murine tumor model by hypericin-mediated PDT. As antioxidants protect cells against phototoxicity, down-regulation of GST activity would potentiate the efficacy of hypericin-PDT treatment. © 2004 Elsevier Ireland Ltd. All rights reserved.
Source Title: Cancer Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/33872
ISSN: 03043835
DOI: 10.1016/j.canlet.2003.12.024
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Dec 6, 2017

WEB OF SCIENCETM
Citations

14
checked on Nov 22, 2017

Page view(s)

87
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.