Please use this identifier to cite or link to this item: https://doi.org/10.3390/cells7030018
Title: MiroWorking beyond Mitochondria and Microtubules
Authors: Tang, Bor Luen 
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
Mitochondrial Rho (Miro)
mitochondria
peroxisome
microtubules
actin
TRANSPORT
MIRO
PHOSPHORYLATION
MOVEMENT
PROTEINS
DYNAMICS
MILTON
MODEL
RAB10
Issue Date: Mar-2018
Publisher: MDPI
Citation: Tang, Bor Luen (2018-03). MiroWorking beyond Mitochondria and Microtubules. CELLS 7 (3). ScholarBank@NUS Repository. https://doi.org/10.3390/cells7030018
Abstract: The small GTPase Miro is best known for its regulation of mitochondrial movement by engaging with the microtubule-based motor proteins kinesin and dynein. Very recent findings have now showed that Miro also targets peroxisomes and regulates microtubule-dependent peroxisome motility. Moreover, Miro recruits and stabilizes the myosin motor Myo19 at the mitochondria to enable actin-based mitochondria movement, which is important for mitochondrial segregation during mitosis. Miro thus has much broader functions that previously known, and these new findings may have important implications on disease pathology.
Source Title: CELLS
URI: https://scholarbank.nus.edu.sg/handle/10635/245927
ISSN: 2073-4409
DOI: 10.3390/cells7030018
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