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https://doi.org/10.3390/ijms24010713
Title: | The Management of Ocular Surface Squamous Neoplasia (OSSN) | Authors: | Yeoh, Clarice HY Lee, Jerome JR Lim, Blanche XH Sundar, Gangadhara Mehta, Jodhbir S Chan, Anita SY Lim, Dawn KA Watson, Stephanie L Honavar, Santosh G Manotosh, Ray Lim, Chris HL |
Keywords: | Science & Technology Life Sciences & Biomedicine Physical Sciences Biochemistry & Molecular Biology Chemistry, Multidisciplinary Chemistry ocular surface squamous neoplasia management topical chemotherapy 5-fluorouracil (5-FU) mitomycin C (MMC) interferon alfa (INF alpha) surgical excision adjuncts TOPICAL MITOMYCIN-C CORNEAL INTRAEPITHELIAL NEOPLASIA AMNIOTIC MEMBRANE TRANSPLANTATION LIMBAL EPITHELIAL TRANSPLANTATION OPTICAL COHERENCE TOMOGRAPHY VIVO CONFOCAL MICROSCOPY HUMAN PAPILLOMA-VIRUS CELL CARCINOMA SUBCONJUNCTIVAL RANIBIZUMAB INTRAOCULAR INVASION |
Issue Date: | Jan-2023 | Publisher: | MDPI | Citation: | Yeoh, Clarice HY, Lee, Jerome JR, Lim, Blanche XH, Sundar, Gangadhara, Mehta, Jodhbir S, Chan, Anita SY, Lim, Dawn KA, Watson, Stephanie L, Honavar, Santosh G, Manotosh, Ray, Lim, Chris HL (2023-01). The Management of Ocular Surface Squamous Neoplasia (OSSN). INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 (1). ScholarBank@NUS Repository. https://doi.org/10.3390/ijms24010713 | Abstract: | The rise of primary topical monotherapy with chemotherapeutic drugs and immunomodulatory agents represents an increasing recognition of the medical management of ocular surface squamous neoplasia (OSSN), which may replace surgery as the standard of care in the future. Currently, there is no consensus regarding the best way to manage OSSN with no existing guidelines to date. This paper seeks to evaluate evidence surrounding available treatment modalities and proposes an approach to management. The approach will guide ophthalmologists in selecting the most appropriate treatment regime based on patient and disease factors to minimize treatment related morbidity and improve OSSN control. Further work can be done to validate this algorithm and to develop formal guidelines to direct the management of OSSN. | Source Title: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | URI: | https://scholarbank.nus.edu.sg/handle/10635/245760 | ISSN: | 1661-6596 1422-0067 |
DOI: | 10.3390/ijms24010713 |
Appears in Collections: | Elements Staff Publications |
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