Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms24010713
Title: The Management of Ocular Surface Squamous Neoplasia (OSSN)
Authors: Yeoh, Clarice HY
Lee, Jerome JR
Lim, Blanche XH
Sundar, Gangadhara 
Mehta, Jodhbir S 
Chan, Anita SY 
Lim, Dawn KA 
Watson, Stephanie L
Honavar, Santosh G
Manotosh, Ray 
Lim, Chris HL
Keywords: Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry
ocular surface squamous neoplasia
management
topical chemotherapy
5-fluorouracil (5-FU)
mitomycin C (MMC)
interferon alfa (INF alpha)
surgical excision
adjuncts
TOPICAL MITOMYCIN-C
CORNEAL INTRAEPITHELIAL NEOPLASIA
AMNIOTIC MEMBRANE TRANSPLANTATION
LIMBAL EPITHELIAL TRANSPLANTATION
OPTICAL COHERENCE TOMOGRAPHY
VIVO CONFOCAL MICROSCOPY
HUMAN PAPILLOMA-VIRUS
CELL CARCINOMA
SUBCONJUNCTIVAL RANIBIZUMAB
INTRAOCULAR INVASION
Issue Date: Jan-2023
Publisher: MDPI
Citation: Yeoh, Clarice HY, Lee, Jerome JR, Lim, Blanche XH, Sundar, Gangadhara, Mehta, Jodhbir S, Chan, Anita SY, Lim, Dawn KA, Watson, Stephanie L, Honavar, Santosh G, Manotosh, Ray, Lim, Chris HL (2023-01). The Management of Ocular Surface Squamous Neoplasia (OSSN). INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 (1). ScholarBank@NUS Repository. https://doi.org/10.3390/ijms24010713
Abstract: The rise of primary topical monotherapy with chemotherapeutic drugs and immunomodulatory agents represents an increasing recognition of the medical management of ocular surface squamous neoplasia (OSSN), which may replace surgery as the standard of care in the future. Currently, there is no consensus regarding the best way to manage OSSN with no existing guidelines to date. This paper seeks to evaluate evidence surrounding available treatment modalities and proposes an approach to management. The approach will guide ophthalmologists in selecting the most appropriate treatment regime based on patient and disease factors to minimize treatment related morbidity and improve OSSN control. Further work can be done to validate this algorithm and to develop formal guidelines to direct the management of OSSN.
Source Title: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
URI: https://scholarbank.nus.edu.sg/handle/10635/245760
ISSN: 1661-6596
1422-0067
DOI: 10.3390/ijms24010713
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