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https://doi.org/10.1016/j.ultsonch.2023.106466
Title: | Ultrasound-assisted formation of chitosan-glucose Maillard reaction products to fabricate nanoparticles with enhanced antioxidant activity | Authors: | Viturat, S Thongngam, M Lumdubwong, N Zhou, W Klinkesorn, U |
Keywords: | Antioxidant activity Chitosan nanoparticle FTIR-analysis Maillard reaction product Tripolyphosphate cross-linking Ultrasound-assisted process Antioxidants Chitosan Glucose Spectroscopy, Fourier Transform Infrared Maillard Reaction Glycation End Products, Advanced Nanoparticles |
Issue Date: | 1-Jul-2023 | Publisher: | Elsevier BV | Citation: | Viturat, S, Thongngam, M, Lumdubwong, N, Zhou, W, Klinkesorn, U (2023-07-01). Ultrasound-assisted formation of chitosan-glucose Maillard reaction products to fabricate nanoparticles with enhanced antioxidant activity. Ultrasonics Sonochemistry 97 : 106466-. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ultsonch.2023.106466 | Abstract: | The influence of ultrasonic processing parameters including reaction temperature (60, 70 and 80 °C), time (0, 15, 30, 45 and 60 min) and amplitude (70, 85 and 100%) on the formation and antioxidant activity of Maillard reaction products (MRPs) in a solution of chitosan and glucose (1.5 wt% at mass ratio of 1:1) was investigated. Selected chitosan-glucose MRPs were further studied to determine the effects of solution pH on the fabrication of antioxidative nanoparticles by ionic crosslinking with sodium tripolyphosphate. Results from FT-IR analysis, zeta-potential determination and color measurement indicated that chitosan-glucose MRPs with improved antioxidant activity were successfully produced using an ultrasound-assisted process. The highest antioxidant activity of MRPs was observed at the reaction temperature, time and amplitude of 80 °C, 60 min and 70%, respectively, with ∼ 34.5 and ∼20.2 μg Trolox mL−1 for DPPH scavenging activity and reducing power, respectively. The pH of both MRPs and tripolyphosphate solutions significantly influenced the fabrication and characteristics of the nanoparticles. Using chitosan-glucose MRPs and tripolyphosphate solution at pH 4.0 generated nanoparticles with enhanced antioxidant activity (∼1.6 and ∼ 1.2 μg Trolox mg−1 for reducing power and DPPH scavenging activity, respectively) with the highest percentage yield (∼59%), intermediate particle size (∼447 nm) and zeta-potential ∼ 19.6 mV. These results present innovative findings for the fabrication of chitosan-based nanoparticles with enhanced antioxidant activity by pre-conjugation with glucose via the Maillard reaction aided by ultrasonic processing. | Source Title: | Ultrasonics Sonochemistry | URI: | https://scholarbank.nus.edu.sg/handle/10635/243376 | ISSN: | 1350-4177 1873-2828 |
DOI: | 10.1016/j.ultsonch.2023.106466 |
Appears in Collections: | Staff Publications Elements |
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