Please use this identifier to cite or link to this item: https://doi.org/10.1002/med.21446
Title: Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action
Authors: Wong, Yin Kwan 
Xu, Chengchao
Kalesh, Karunakaran A
He, Yingke 
Lin, Qingsong
Wong, WS Fred 
Shen, Han-Ming 
Wang, Jigang 
Keywords: Science & Technology
Life Sciences & Biomedicine
Chemistry, Medicinal
Pharmacology & Pharmacy
artemisinin
anticancer
targets identification
mechanism of action
chemical proteomics
DIHYDROARTEMISININ INDUCES APOPTOSIS
OVARIAN-CANCER CELLS
PEGYLATED NANOLIPOSOMAL ARTEMISININ
TUMOR PROTEIN TCTP
PLASMODIUM-FALCIPARUM
IN-VITRO
MOLECULAR TARGETS
ARTESUNATE EXERTS
CERVICAL-CANCER
DNA-DAMAGE
Issue Date: 1-Nov-2017
Publisher: WILEY
Citation: Wong, Yin Kwan, Xu, Chengchao, Kalesh, Karunakaran A, He, Yingke, Lin, Qingsong, Wong, WS Fred, Shen, Han-Ming, Wang, Jigang (2017-11-01). Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action. MEDICINAL RESEARCH REVIEWS 37 (6) : 1492-1517. ScholarBank@NUS Repository. https://doi.org/10.1002/med.21446
Abstract: Artemisinin and its derivatives (collectively termed as artemisinins) are among the most important and effective antimalarial drugs, with proven safety and efficacy in clinical use. Beyond their antimalarial effects, artemisinins have also been shown to possess selective anticancer properties, demonstrating cytotoxic effects against a wide range of cancer types both in vitro and in vivo. These effects appear to be mediated by artemisinin-induced changes in multiple signaling pathways, interfering simultaneously with multiple hallmarks of cancer. Great strides have been taken to characterize these pathways and to reveal their anticancer mechanisms of action of artemisinin. Moreover, encouraging data have also been obtained from a limited number of clinical trials to support their anticancer property. However, there are several key gaps in knowledge that continue to serve as significant barriers to the repurposing of artemisinins as effective anticancer agents. This review focuses on important and emerging aspects of this field, highlighting breakthroughs in unresolved questions as well as novel techniques and approaches that have been taken in recent studies. We discuss the mechanism of artemisinin activation in cancer, novel and significant findings with regards to artemisinin target proteins and pathways, new understandings in artemisinin-induced cell death mechanisms, as well as the practical issues of repurposing artemisinin. We believe these will be important topics in realizing the potential of artemisinin and its derivatives as safe and potent anticancer agents.
Source Title: MEDICINAL RESEARCH REVIEWS
URI: https://scholarbank.nus.edu.sg/handle/10635/239316
ISSN: 0198-6325
1098-1128
DOI: 10.1002/med.21446
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