Please use this identifier to cite or link to this item: https://doi.org/10.1002/med.21446
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dc.titleArtemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action
dc.contributor.authorWong, Yin Kwan
dc.contributor.authorXu, Chengchao
dc.contributor.authorKalesh, Karunakaran A
dc.contributor.authorHe, Yingke
dc.contributor.authorLin, Qingsong
dc.contributor.authorWong, WS Fred
dc.contributor.authorShen, Han-Ming
dc.contributor.authorWang, Jigang
dc.date.accessioned2023-05-11T08:00:30Z
dc.date.available2023-05-11T08:00:30Z
dc.date.issued2017-11-01
dc.identifier.citationWong, Yin Kwan, Xu, Chengchao, Kalesh, Karunakaran A, He, Yingke, Lin, Qingsong, Wong, WS Fred, Shen, Han-Ming, Wang, Jigang (2017-11-01). Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action. MEDICINAL RESEARCH REVIEWS 37 (6) : 1492-1517. ScholarBank@NUS Repository. https://doi.org/10.1002/med.21446
dc.identifier.issn0198-6325
dc.identifier.issn1098-1128
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/239316
dc.description.abstractArtemisinin and its derivatives (collectively termed as artemisinins) are among the most important and effective antimalarial drugs, with proven safety and efficacy in clinical use. Beyond their antimalarial effects, artemisinins have also been shown to possess selective anticancer properties, demonstrating cytotoxic effects against a wide range of cancer types both in vitro and in vivo. These effects appear to be mediated by artemisinin-induced changes in multiple signaling pathways, interfering simultaneously with multiple hallmarks of cancer. Great strides have been taken to characterize these pathways and to reveal their anticancer mechanisms of action of artemisinin. Moreover, encouraging data have also been obtained from a limited number of clinical trials to support their anticancer property. However, there are several key gaps in knowledge that continue to serve as significant barriers to the repurposing of artemisinins as effective anticancer agents. This review focuses on important and emerging aspects of this field, highlighting breakthroughs in unresolved questions as well as novel techniques and approaches that have been taken in recent studies. We discuss the mechanism of artemisinin activation in cancer, novel and significant findings with regards to artemisinin target proteins and pathways, new understandings in artemisinin-induced cell death mechanisms, as well as the practical issues of repurposing artemisinin. We believe these will be important topics in realizing the potential of artemisinin and its derivatives as safe and potent anticancer agents.
dc.language.isoen
dc.publisherWILEY
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectChemistry, Medicinal
dc.subjectPharmacology & Pharmacy
dc.subjectartemisinin
dc.subjectanticancer
dc.subjecttargets identification
dc.subjectmechanism of action
dc.subjectchemical proteomics
dc.subjectDIHYDROARTEMISININ INDUCES APOPTOSIS
dc.subjectOVARIAN-CANCER CELLS
dc.subjectPEGYLATED NANOLIPOSOMAL ARTEMISININ
dc.subjectTUMOR PROTEIN TCTP
dc.subjectPLASMODIUM-FALCIPARUM
dc.subjectIN-VITRO
dc.subjectMOLECULAR TARGETS
dc.subjectARTESUNATE EXERTS
dc.subjectCERVICAL-CANCER
dc.subjectDNA-DAMAGE
dc.typeReview
dc.date.updated2023-05-11T06:02:19Z
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1002/med.21446
dc.description.sourcetitleMEDICINAL RESEARCH REVIEWS
dc.description.volume37
dc.description.issue6
dc.description.page1492-1517
dc.published.statePublished
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