Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.it.2018.08.004
| Title: | Hiding in Plain Sight: Soluble Immunomodulatory Receptors | Authors: | Dahal, LN Schwarz, H Ward, FJ |
Keywords: | Animals Antibodies, Monoclonal B7-H1 Antigen CTLA-4 Antigen Humans Immunotherapy Molecular Targeted Therapy Neoplasms Programmed Cell Death 1 Receptor Tumor Necrosis Factor Receptor Superfamily, Member 9 |
Issue Date: | 1-Oct-2018 | Publisher: | Elsevier BV | Citation: | Dahal, LN, Schwarz, H, Ward, FJ (2018-10-01). Hiding in Plain Sight: Soluble Immunomodulatory Receptors. Trends in Immunology 39 (10) : 771-774. ScholarBank@NUS Repository. https://doi.org/10.1016/j.it.2018.08.004 | Abstract: | Alternatively spliced natural soluble isoforms of immunomodulatory receptors [cytotoxic T lymphocyte antigen-4 (CTLA-4), 4-1BB, and programmed death-1 (PD-1)/PD-L1] have been overlooked in favor of their cell-surface-bound counterparts that have generated blockbuster antibodies for the treatment of cancer. We propose that the soluble variants of these receptors contribute to immune regulation and offer potential as targets for immunotherapy. | Source Title: | Trends in Immunology | URI: | https://scholarbank.nus.edu.sg/handle/10635/239115 | ISSN: | 1471-4906 1471-4981 |
DOI: | 10.1016/j.it.2018.08.004 |
| Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
| File | Description | Size | Format | Access Settings | Version | |
|---|---|---|---|---|---|---|
| Dahal 2018.pdf | 654.54 kB | Adobe PDF | CLOSED | Published |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.