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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.it.2018.08.004
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dc.titleHiding in Plain Sight: Soluble Immunomodulatory Receptors
dc.contributor.authorDahal, LN
dc.contributor.authorSchwarz, H
dc.contributor.authorWard, FJ
dc.date.accessioned2023-05-02T09:48:37Z
dc.date.available2023-05-02T09:48:37Z
dc.date.issued2018-10-01
dc.identifier.citationDahal, LN, Schwarz, H, Ward, FJ (2018-10-01). Hiding in Plain Sight: Soluble Immunomodulatory Receptors. Trends in Immunology 39 (10) : 771-774. ScholarBank@NUS Repository. https://doi.org/10.1016/j.it.2018.08.004
dc.identifier.issn1471-4906
dc.identifier.issn1471-4981
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/239115
dc.description.abstractAlternatively spliced natural soluble isoforms of immunomodulatory receptors [cytotoxic T lymphocyte antigen-4 (CTLA-4), 4-1BB, and programmed death-1 (PD-1)/PD-L1] have been overlooked in favor of their cell-surface-bound counterparts that have generated blockbuster antibodies for the treatment of cancer. We propose that the soluble variants of these receptors contribute to immune regulation and offer potential as targets for immunotherapy.
dc.publisherElsevier BV
dc.sourceElements
dc.subjectAnimals
dc.subjectAntibodies, Monoclonal
dc.subjectB7-H1 Antigen
dc.subjectCTLA-4 Antigen
dc.subjectHumans
dc.subjectImmunotherapy
dc.subjectMolecular Targeted Therapy
dc.subjectNeoplasms
dc.subjectProgrammed Cell Death 1 Receptor
dc.subjectTumor Necrosis Factor Receptor Superfamily, Member 9
dc.typeArticle
dc.date.updated2023-05-02T08:23:02Z
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1016/j.it.2018.08.004
dc.description.sourcetitleTrends in Immunology
dc.description.volume39
dc.description.issue10
dc.description.page771-774
dc.published.statePublished
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