Please use this identifier to cite or link to this item:
Title: Associations of maternal and foetoplacental factors with prehypertension/hypertension in early childhood
Authors: Michael N
Sadananthan SA 
Yuan WL 
Ong YY 
Loy SL 
Huang JY 
Tint MT 
Padmapriya N 
Choo J 
Ling LH 
Kramer MS 
Godfrey KM
Gluckman PD 
Tan KH 
Eriksson JG 
Chong YS 
Lee YS 
Karnani N 
Yap F 
Shek LP 
Fortier MV 
Moritz KM
Chan SY 
Velan SS 
Wlodek ME 
Keywords: Low birthweight
childhood prehypertension
fetal growth
placental insufficiency
pregnancy complications
mother-offspring cohort study
Issue Date: 1-Nov-2022
Publisher: Wolters Kluwer N.V.
Citation: Michael N, Sadananthan SA, Yuan WL, Ong YY, Loy SL, Huang JY, Tint MT, Padmapriya N, Choo J, Ling LH, Kramer MS, Godfrey KM, Gluckman PD, Tan KH, Eriksson JG, Chong YS, Lee YS, Karnani N, Yap F, Shek LP, Fortier MV, Moritz KM, Chan SY, Velan SS, Wlodek ME (2022-11-01). Associations of maternal and foetoplacental factors with prehypertension/hypertension in early childhood. Journal of Hypertension 40 (11) : 2171-2179. ScholarBank@NUS Repository.
Abstract: Objective: To evaluate whether characterization of maternal and foetoplacental factors beyond birthweight can enable early identification of children at risk of developing prehypertension/hypertension. Methods: We recruited 693 mother-offspring dyads from the GUSTO prospective mother-offspring cohort. Prehypertension/hypertension at age 6 years was identified using the simplified paediatric threshold of 110/70 mmHg. We evaluated the associations of pregnancy complications (gestational diabetes, excessive/inadequate gestational weight gain, hypertensive disorders of pregnancy), foetal growth deceleration (decline in foetal abdominal circumference at least 0.67 standard deviations between second and third trimesters), high foetoplacental vascular resistance (third trimester umbilical artery systolic-to-diastolic ratio ?90th centile), preterm birth, small-for-gestational age and neonatal kidney volumes with risk of prehypertension/hypertension at age 6 years, after adjusting for sex, ethnicity, maternal education and prepregnancy BMI. Results: Pregnancy complications, small-for-gestational age, preterm birth, and low neonatal kidney volume were not associated with an increased risk of prehypertension/hypertension at age 6 years. In contrast, foetal growth deceleration was associated with a 72% higher risk [risk ratio (RR) = 1.72, 95% confidence interval (CI) 1.18-2.52]. High foetoplacental vascular resistance was associated with a 58% higher risk (RR = 1.58, 95% CI 0.96-2.62). Having both these characteristics, relative to having neither, was associated with over two-fold higher risk (RR = 2.55, 95% CI 1.26-5.16). Over 85% of the foetuses with either of these characteristics were born appropriate or large for gestational age. Conclusion: Foetal growth deceleration and high foetoplacental vascular resistance may be helpful in prioritizing high-risk children for regular blood pressure monitoring and preventive interventions, across the birthweight spectrum.
Source Title: Journal of Hypertension
ISSN: 0263-6352
DOI: 10.1097/HJH.0000000000003241
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
(337)_postprint_Associations of maternal and foetoplacental factors with prehypertension-hypertension in early childhood.zip160.4 kBZIP



Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.