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https://doi.org/10.3390/biomedicines10112681
Title: | Prior Cancer Is Associated with Lower Atherosclerotic Cardiovascular Disease Risk at First Acute Myocardial Infarction | Authors: | Koo, Chieh Yang Zheng, Huili Tan, Li Ling Foo, Ling-Li Hausenloy, Derek J Chng, Wee-Joo Lee, Soo Chin Richards, Arthur Mark Ling, Lieng-Hsi Lim, Shir Lynn Lee, Chi-Hang Chan, Mark Y |
Keywords: | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Medicine, Research & Experimental Pharmacology & Pharmacy Research & Experimental Medicine cardio-oncology coronary artery disease preventive cardiology cancer survivorship risk factors ADULT CANCERS SURVIVORS INFLAMMATION |
Issue Date: | 1-Nov-2022 | Publisher: | MDPI | Citation: | Koo, Chieh Yang, Zheng, Huili, Tan, Li Ling, Foo, Ling-Li, Hausenloy, Derek J, Chng, Wee-Joo, Lee, Soo Chin, Richards, Arthur Mark, Ling, Lieng-Hsi, Lim, Shir Lynn, Lee, Chi-Hang, Chan, Mark Y (2022-11-01). Prior Cancer Is Associated with Lower Atherosclerotic Cardiovascular Disease Risk at First Acute Myocardial Infarction. BIOMEDICINES 10 (11). ScholarBank@NUS Repository. https://doi.org/10.3390/biomedicines10112681 | Abstract: | Background: Patients with cancer are at increased risk of acute myocardial infarction (AMI). It is unclear if the Atherosclerotic Cardiovascular Disease (ASCVD) risk score at incident AMI is reflective of this higher risk in patients with prior cancer than those without. Methods: We linked nationwide AMI and cancer registries from 2008 to 2019. A total of 18,200 eligible patients with ASCVD risk score calculated at incident AMI were identified (1086 prior cancer; 17,114 no cancer). Results: At incident AMI, age-standardized mean ASCVD risk was lower in the prior cancer group (18.6%) than no cancer group (20.9%) (p < 0.001). Prior to incident AMI, smoking, hypertension, hyperlipidemia and diabetes mellitus were better controlled in the prior cancer group. However post-AMI, prior cancer was associated with lower guideline-directed medical therapy usage and higher all-cause mortality (adjusted hazard ratio 1.85, 95% confidence interval 1.66–2.07). Conclusions: AMI occurred despite better control of cardiovascular risk factors and lower age-standardized estimated mean 10-year ASCVD risk among patients with prior cancer than no cancer. Prior cancer was associated with lower guideline-directed medical therapy post-AMI and higher mortality. | Source Title: | BIOMEDICINES | URI: | https://scholarbank.nus.edu.sg/handle/10635/237479 | ISSN: | 2227-9059 | DOI: | 10.3390/biomedicines10112681 |
Appears in Collections: | Staff Publications Elements |
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