Please use this identifier to cite or link to this item: https://doi.org/10.3390/biomedicines10112681
Title: Prior Cancer Is Associated with Lower Atherosclerotic Cardiovascular Disease Risk at First Acute Myocardial Infarction
Authors: Koo, Chieh Yang 
Zheng, Huili 
Tan, Li Ling 
Foo, Ling-Li
Hausenloy, Derek J 
Chng, Wee-Joo 
Lee, Soo Chin 
Richards, Arthur Mark 
Ling, Lieng-Hsi 
Lim, Shir Lynn 
Lee, Chi-Hang 
Chan, Mark Y
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Medicine, Research & Experimental
Pharmacology & Pharmacy
Research & Experimental Medicine
cardio-oncology
coronary artery disease
preventive cardiology
cancer survivorship
risk factors
ADULT CANCERS
SURVIVORS
INFLAMMATION
Issue Date: 1-Nov-2022
Publisher: MDPI
Citation: Koo, Chieh Yang, Zheng, Huili, Tan, Li Ling, Foo, Ling-Li, Hausenloy, Derek J, Chng, Wee-Joo, Lee, Soo Chin, Richards, Arthur Mark, Ling, Lieng-Hsi, Lim, Shir Lynn, Lee, Chi-Hang, Chan, Mark Y (2022-11-01). Prior Cancer Is Associated with Lower Atherosclerotic Cardiovascular Disease Risk at First Acute Myocardial Infarction. BIOMEDICINES 10 (11). ScholarBank@NUS Repository. https://doi.org/10.3390/biomedicines10112681
Abstract: Background: Patients with cancer are at increased risk of acute myocardial infarction (AMI). It is unclear if the Atherosclerotic Cardiovascular Disease (ASCVD) risk score at incident AMI is reflective of this higher risk in patients with prior cancer than those without. Methods: We linked nationwide AMI and cancer registries from 2008 to 2019. A total of 18,200 eligible patients with ASCVD risk score calculated at incident AMI were identified (1086 prior cancer; 17,114 no cancer). Results: At incident AMI, age-standardized mean ASCVD risk was lower in the prior cancer group (18.6%) than no cancer group (20.9%) (p < 0.001). Prior to incident AMI, smoking, hypertension, hyperlipidemia and diabetes mellitus were better controlled in the prior cancer group. However post-AMI, prior cancer was associated with lower guideline-directed medical therapy usage and higher all-cause mortality (adjusted hazard ratio 1.85, 95% confidence interval 1.66–2.07). Conclusions: AMI occurred despite better control of cardiovascular risk factors and lower age-standardized estimated mean 10-year ASCVD risk among patients with prior cancer than no cancer. Prior cancer was associated with lower guideline-directed medical therapy post-AMI and higher mortality.
Source Title: BIOMEDICINES
URI: https://scholarbank.nus.edu.sg/handle/10635/237479
ISSN: 2227-9059
DOI: 10.3390/biomedicines10112681
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