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Title: Association between Breast Cancer Polygenic Risk Score and Chemotherapy-Induced Febrile Neutropenia: Null Results
Authors: Ong, Seeu Si
Ho, Peh Joo 
Khng, Alexis Jiaying
Lim, Elaine Hsuen 
Wong, Fuh Yong 
Tan, Benita Kiat-Tee 
Lim, Swee Ho 
Tan, Ern Yu
Tan, Su-Ming 
Tan, Veronique Kiak Mien 
Dent, Rebecca 
Tan, Tira Jing Ying 
Ngeow, Joanne 
Madhukumar, Preetha 
Hamzah, Julie Liana Bte
Sim, Yirong 
Lim, Geok Hoon 
Pang, Jinnie Siyan
Alcantara, Veronica Siton
Chan, Patrick Mun Yew 
Chen, Juliana Jia Chuan 
Kuah, Sherwin
Seah, Jaime Chin Mui
Buhari, Shaik Ahmad 
Tang, Siau Wei 
Ng, Celene Wei Qi 
Li, Jingmei 
Hartman, Mikael 
Keywords: Science & Technology
Life Sciences & Biomedicine
febrile neutropenia
neutropenic fever
breast cancer
polygenic risk score
Issue Date: 1-Jun-2022
Publisher: MDPI
Citation: Ong, Seeu Si, Ho, Peh Joo, Khng, Alexis Jiaying, Lim, Elaine Hsuen, Wong, Fuh Yong, Tan, Benita Kiat-Tee, Lim, Swee Ho, Tan, Ern Yu, Tan, Su-Ming, Tan, Veronique Kiak Mien, Dent, Rebecca, Tan, Tira Jing Ying, Ngeow, Joanne, Madhukumar, Preetha, Hamzah, Julie Liana Bte, Sim, Yirong, Lim, Geok Hoon, Pang, Jinnie Siyan, Alcantara, Veronica Siton, Chan, Patrick Mun Yew, Chen, Juliana Jia Chuan, Kuah, Sherwin, Seah, Jaime Chin Mui, Buhari, Shaik Ahmad, Tang, Siau Wei, Ng, Celene Wei Qi, Li, Jingmei, Hartman, Mikael (2022-06-01). Association between Breast Cancer Polygenic Risk Score and Chemotherapy-Induced Febrile Neutropenia: Null Results. CANCERS 14 (11). ScholarBank@NUS Repository.
Abstract: Background: The hypothesis that breast cancer (BC) susceptibility variants are linked to chemotherapy-induced toxicity has been previously explored. Here, we investigated the association between a validated 313-marker-based BC polygenic risk score (PRS) and chemotherapy-induced neutropenia without fever and febrile neutropenia (FNc) in Asian BC patients. Methods: This observational case-control study of Asian BC patients treated with chemotherapy included 161 FNc patients, 219 neutropenia patients, and 936 patients who did not develop neutropenia. A continuous PRS was calculated by summing weighted risk alleles associated with overall, estrogen receptor-(ER-) positive, and ER-negative BC risk. PRS distributions neutropenia or FNc cases were compared to controls who did not develop neutropenia using two-sample t-tests. Odds ratios (OR) and corresponding 95% confidence intervals were estimated for the associations between PRS (quartiles and per standard deviation (SD) increase) and neutropenia-related outcomes compared to controls. Results: PRS distributions were not significantly different in any of the comparisons. Higher PRSoverall quartiles were negatively correlated with neutropenia or FNc. However, the associations were not statistically significant (PRS per SD increase OR neutropenia: 0.91 [0.79–1.06]; FNc: 0.87 [0.73–1.03]). No dose-dependent trend was observed for the ER-positive weighted PRS (PRSER-pos ) and ER-negative weighted PRS (PRSER-neg ). Conclusion: BC PRS was not strongly associated with chemotherapy-induced neutropenia or FNc.
Source Title: CANCERS
ISSN: 2072-6694
DOI: 10.3390/cancers14112714
Appears in Collections:Staff Publications

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