Please use this identifier to cite or link to this item:
https://doi.org/10.3390/cancers14112714
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dc.title | Association between Breast Cancer Polygenic Risk Score and Chemotherapy-Induced Febrile Neutropenia: Null Results | |
dc.contributor.author | Ong, Seeu Si | |
dc.contributor.author | Ho, Peh Joo | |
dc.contributor.author | Khng, Alexis Jiaying | |
dc.contributor.author | Lim, Elaine Hsuen | |
dc.contributor.author | Wong, Fuh Yong | |
dc.contributor.author | Tan, Benita Kiat-Tee | |
dc.contributor.author | Lim, Swee Ho | |
dc.contributor.author | Tan, Ern Yu | |
dc.contributor.author | Tan, Su-Ming | |
dc.contributor.author | Tan, Veronique Kiak Mien | |
dc.contributor.author | Dent, Rebecca | |
dc.contributor.author | Tan, Tira Jing Ying | |
dc.contributor.author | Ngeow, Joanne | |
dc.contributor.author | Madhukumar, Preetha | |
dc.contributor.author | Hamzah, Julie Liana Bte | |
dc.contributor.author | Sim, Yirong | |
dc.contributor.author | Lim, Geok Hoon | |
dc.contributor.author | Pang, Jinnie Siyan | |
dc.contributor.author | Alcantara, Veronica Siton | |
dc.contributor.author | Chan, Patrick Mun Yew | |
dc.contributor.author | Chen, Juliana Jia Chuan | |
dc.contributor.author | Kuah, Sherwin | |
dc.contributor.author | Seah, Jaime Chin Mui | |
dc.contributor.author | Buhari, Shaik Ahmad | |
dc.contributor.author | Tang, Siau Wei | |
dc.contributor.author | Ng, Celene Wei Qi | |
dc.contributor.author | Li, Jingmei | |
dc.contributor.author | Hartman, Mikael | |
dc.date.accessioned | 2023-02-22T02:21:24Z | |
dc.date.available | 2023-02-22T02:21:24Z | |
dc.date.issued | 2022-06-01 | |
dc.identifier.citation | Ong, Seeu Si, Ho, Peh Joo, Khng, Alexis Jiaying, Lim, Elaine Hsuen, Wong, Fuh Yong, Tan, Benita Kiat-Tee, Lim, Swee Ho, Tan, Ern Yu, Tan, Su-Ming, Tan, Veronique Kiak Mien, Dent, Rebecca, Tan, Tira Jing Ying, Ngeow, Joanne, Madhukumar, Preetha, Hamzah, Julie Liana Bte, Sim, Yirong, Lim, Geok Hoon, Pang, Jinnie Siyan, Alcantara, Veronica Siton, Chan, Patrick Mun Yew, Chen, Juliana Jia Chuan, Kuah, Sherwin, Seah, Jaime Chin Mui, Buhari, Shaik Ahmad, Tang, Siau Wei, Ng, Celene Wei Qi, Li, Jingmei, Hartman, Mikael (2022-06-01). Association between Breast Cancer Polygenic Risk Score and Chemotherapy-Induced Febrile Neutropenia: Null Results. CANCERS 14 (11). ScholarBank@NUS Repository. https://doi.org/10.3390/cancers14112714 | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/237403 | |
dc.description.abstract | Background: The hypothesis that breast cancer (BC) susceptibility variants are linked to chemotherapy-induced toxicity has been previously explored. Here, we investigated the association between a validated 313-marker-based BC polygenic risk score (PRS) and chemotherapy-induced neutropenia without fever and febrile neutropenia (FNc) in Asian BC patients. Methods: This observational case-control study of Asian BC patients treated with chemotherapy included 161 FNc patients, 219 neutropenia patients, and 936 patients who did not develop neutropenia. A continuous PRS was calculated by summing weighted risk alleles associated with overall, estrogen receptor-(ER-) positive, and ER-negative BC risk. PRS distributions neutropenia or FNc cases were compared to controls who did not develop neutropenia using two-sample t-tests. Odds ratios (OR) and corresponding 95% confidence intervals were estimated for the associations between PRS (quartiles and per standard deviation (SD) increase) and neutropenia-related outcomes compared to controls. Results: PRS distributions were not significantly different in any of the comparisons. Higher PRSoverall quartiles were negatively correlated with neutropenia or FNc. However, the associations were not statistically significant (PRS per SD increase OR neutropenia: 0.91 [0.79–1.06]; FNc: 0.87 [0.73–1.03]). No dose-dependent trend was observed for the ER-positive weighted PRS (PRSER-pos ) and ER-negative weighted PRS (PRSER-neg ). Conclusion: BC PRS was not strongly associated with chemotherapy-induced neutropenia or FNc. | |
dc.language.iso | en | |
dc.publisher | MDPI | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Oncology | |
dc.subject | febrile neutropenia | |
dc.subject | neutropenic fever | |
dc.subject | breast cancer | |
dc.subject | polygenic risk score | |
dc.subject | PRS | |
dc.subject | SOLID TUMORS | |
dc.subject | HOSPITALIZATIONS | |
dc.subject | POLYMORPHISMS | |
dc.subject | DOCETAXEL | |
dc.subject | MORTALITY | |
dc.subject | TOXICITY | |
dc.type | Article | |
dc.date.updated | 2023-02-21T06:54:16Z | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | SURGERY | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.3390/cancers14112714 | |
dc.description.sourcetitle | CANCERS | |
dc.description.volume | 14 | |
dc.description.issue | 11 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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Association between Breast Cancer Polygenic Risk Score and Chemotherapy-Induced Febrile Neutropenia Null Results.pdf | 1.33 MB | Adobe PDF | OPEN | Published | View/Download |
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