Please use this identifier to cite or link to this item: https://doi.org/10.1159/000442382
Title: Profile of the Paraoxonase 1 (PON1) Gene 192Q/R Polymorphism and Clinical Associations among Older Singaporean Chinese with Alzheimer's and Mixed Dementia
Authors: Seow, Dennis CC 
Gao, Qi
Yap, Philip 
Gan, Jia Min
Chionh, Hui Ling
Lim, Su Chi 
Feng, Lei 
Ng, Tze Pin 
Keywords: Paraoxonase 1
Alzheimer's disease
Mixed dementia
Singaporean Chinese elderly
Neuropsychiatric symptoms
Issue Date: 2016
Publisher: S. Karger AG
Citation: Seow, Dennis CC, Gao, Qi, Yap, Philip, Gan, Jia Min, Chionh, Hui Ling, Lim, Su Chi, Feng, Lei, Ng, Tze Pin (2016). Profile of the Paraoxonase 1 (PON1) Gene 192Q/R Polymorphism and Clinical Associations among Older Singaporean Chinese with Alzheimer's and Mixed Dementia. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA 6 (1) : 43-54. ScholarBank@NUS Repository. https://doi.org/10.1159/000442382
Abstract: Background: To examine the prevalence of the Paraoxonase1 (PON1) gene 192Q/R polymorphism amongst Singaporean Chinese with Alzheimer's disease (AD) and mixed dementia and possible clinical associations. Methods: We examined the presence of the PON1 192Q/R polymorphism together with cognitive status, functional status and neuropsychiatric symptoms among 186 older Singaporean Chinese with AD (n = 109) and mixed dementia (n = 77). Results: The R allele predominated in 67% of the AD patients and 63.1% of the patients with mixed dementia. Within the mixed dementia subgroup, the R allele was significantly associated with a higher BADLS score, NPI-Q scores and CDR scores. Conclusion: Among older Singaporean Chinese with AD and mixed dementia, the R allele was predominant. In particular, within the mixed dementia subgroup, the R allele carrier status was associated with poorer functional status, greater presence of neuropsychiatric symptoms and a more severe stage of dementia. Further studies should be conducted.
Source Title: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA
URI: https://scholarbank.nus.edu.sg/handle/10635/235157
ISSN: 1664-5464
DOI: 10.1159/000442382
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Profile of the Paraoxonase 1 (PON1) Gene 192QR Polymorphism and Clinical Associations among Older Singaporean Chinese with A.pdf1.39 MBAdobe PDF

OPEN

NoneView/Download
Profile of the Paraoxonase 1 (PON1) Gene 192QR Polymorphism and Clinical Associations among Older Singaporean Chinese with A.pdf1.39 MBAdobe PDF

OPEN

NoneView/Download
Profile of the Paraoxonase 1 (PON1) Gene 192QR Polymorphism and Clinical Associations among Older Singaporean Chinese with A.pdf1.39 MBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.