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https://doi.org/10.1159/000442382
Title: | Profile of the Paraoxonase 1 (PON1) Gene 192Q/R Polymorphism and Clinical Associations among Older Singaporean Chinese with Alzheimer's and Mixed Dementia | Authors: | Seow, Dennis CC Gao, Qi Yap, Philip Gan, Jia Min Chionh, Hui Ling Lim, Su Chi Feng, Lei Ng, Tze Pin |
Keywords: | Paraoxonase 1 Alzheimer's disease Mixed dementia Singaporean Chinese elderly Neuropsychiatric symptoms |
Issue Date: | 2016 | Publisher: | S. Karger AG | Citation: | Seow, Dennis CC, Gao, Qi, Yap, Philip, Gan, Jia Min, Chionh, Hui Ling, Lim, Su Chi, Feng, Lei, Ng, Tze Pin (2016). Profile of the Paraoxonase 1 (PON1) Gene 192Q/R Polymorphism and Clinical Associations among Older Singaporean Chinese with Alzheimer's and Mixed Dementia. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA 6 (1) : 43-54. ScholarBank@NUS Repository. https://doi.org/10.1159/000442382 | Abstract: | Background: To examine the prevalence of the Paraoxonase1 (PON1) gene 192Q/R polymorphism amongst Singaporean Chinese with Alzheimer's disease (AD) and mixed dementia and possible clinical associations. Methods: We examined the presence of the PON1 192Q/R polymorphism together with cognitive status, functional status and neuropsychiatric symptoms among 186 older Singaporean Chinese with AD (n = 109) and mixed dementia (n = 77). Results: The R allele predominated in 67% of the AD patients and 63.1% of the patients with mixed dementia. Within the mixed dementia subgroup, the R allele was significantly associated with a higher BADLS score, NPI-Q scores and CDR scores. Conclusion: Among older Singaporean Chinese with AD and mixed dementia, the R allele was predominant. In particular, within the mixed dementia subgroup, the R allele carrier status was associated with poorer functional status, greater presence of neuropsychiatric symptoms and a more severe stage of dementia. Further studies should be conducted. | Source Title: | DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA | URI: | https://scholarbank.nus.edu.sg/handle/10635/235157 | ISSN: | 1664-5464 | DOI: | 10.1159/000442382 |
Appears in Collections: | Staff Publications Elements |
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Profile of the Paraoxonase 1 (PON1) Gene 192QR Polymorphism and Clinical Associations among Older Singaporean Chinese with A.pdf | 1.39 MB | Adobe PDF | OPEN | None | View/Download | |
Profile of the Paraoxonase 1 (PON1) Gene 192QR Polymorphism and Clinical Associations among Older Singaporean Chinese with A.pdf | 1.39 MB | Adobe PDF | OPEN | None | View/Download | |
Profile of the Paraoxonase 1 (PON1) Gene 192QR Polymorphism and Clinical Associations among Older Singaporean Chinese with A.pdf | 1.39 MB | Adobe PDF | OPEN | None | View/Download |
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