Please use this identifier to cite or link to this item: https://doi.org/10.3389/fphys.2019.00996
Title: Age-Related DNA Methylation Changes: Potential Impact on Skeletal Muscle Aging in Humans
Authors: Gensous, Noernie
Bacalini, Maria Giulia
Franceschi, Claudio
Meskers, Carel GM
Maier, Andrea B 
Garagnani, Paolo
Keywords: Science & Technology
Life Sciences & Biomedicine
Physiology
aging
muscle
sarcopenia
epigenetics
DNA methylation
epigenetic clocks
GENE-EXPRESSION PROFILE
ALL-CAUSE MORTALITY
STEM-CELL POOL
EPIGENETIC FACTORS
HANDGRIP STRENGTH
ANALYSIS REVEALS
OLDER-ADULTS
EXERCISE
SARCOPENIA
DISEASE
Issue Date: 2-Aug-2019
Publisher: FRONTIERS MEDIA SA
Citation: Gensous, Noernie, Bacalini, Maria Giulia, Franceschi, Claudio, Meskers, Carel GM, Maier, Andrea B, Garagnani, Paolo (2019-08-02). Age-Related DNA Methylation Changes: Potential Impact on Skeletal Muscle Aging in Humans. FRONTIERS IN PHYSIOLOGY 10 (JUL). ScholarBank@NUS Repository. https://doi.org/10.3389/fphys.2019.00996
Abstract: Human aging is accompanied by a decline in muscle mass and muscle function, which is commonly referred to as sarcopenia. Sarcopenia is associated with detrimental clinical outcomes, such as a reduced quality of life, frailty, an increased risk of falls, fractures, hospitalization, and mortality. The exact underlying mechanisms of sarcopenia are poorly delineated and the molecular mechanisms driving the development and progression of this disorder remain to be uncovered. Previous studies have described age-related differences in gene expression, with one study identifying an age-specific expression signature of sarcopenia, but little is known about the influence of epigenetics, and specially of DNA methylation, in its pathogenesis. In this review, we will focus on the available knowledge in literature on the characterization of DNA methylation profiles during skeletal muscle aging and the possible impact of physical activity and nutrition. We will consider the possible use of the recently developed DNA methylation-based biomarkers of aging called epigenetic clocks in the assessment of physical performance in older individuals. Finally, we will discuss limitations and future directions of this field.
Source Title: FRONTIERS IN PHYSIOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/234969
ISSN: 1664-042X
DOI: 10.3389/fphys.2019.00996
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