Please use this identifier to cite or link to this item: https://doi.org/10.3389/fphys.2019.00996
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dc.titleAge-Related DNA Methylation Changes: Potential Impact on Skeletal Muscle Aging in Humans
dc.contributor.authorGensous, Noernie
dc.contributor.authorBacalini, Maria Giulia
dc.contributor.authorFranceschi, Claudio
dc.contributor.authorMeskers, Carel GM
dc.contributor.authorMaier, Andrea B
dc.contributor.authorGaragnani, Paolo
dc.date.accessioned2022-11-30T06:25:43Z
dc.date.available2022-11-30T06:25:43Z
dc.date.issued2019-08-02
dc.identifier.citationGensous, Noernie, Bacalini, Maria Giulia, Franceschi, Claudio, Meskers, Carel GM, Maier, Andrea B, Garagnani, Paolo (2019-08-02). Age-Related DNA Methylation Changes: Potential Impact on Skeletal Muscle Aging in Humans. FRONTIERS IN PHYSIOLOGY 10 (JUL). ScholarBank@NUS Repository. https://doi.org/10.3389/fphys.2019.00996
dc.identifier.issn1664-042X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/234969
dc.description.abstractHuman aging is accompanied by a decline in muscle mass and muscle function, which is commonly referred to as sarcopenia. Sarcopenia is associated with detrimental clinical outcomes, such as a reduced quality of life, frailty, an increased risk of falls, fractures, hospitalization, and mortality. The exact underlying mechanisms of sarcopenia are poorly delineated and the molecular mechanisms driving the development and progression of this disorder remain to be uncovered. Previous studies have described age-related differences in gene expression, with one study identifying an age-specific expression signature of sarcopenia, but little is known about the influence of epigenetics, and specially of DNA methylation, in its pathogenesis. In this review, we will focus on the available knowledge in literature on the characterization of DNA methylation profiles during skeletal muscle aging and the possible impact of physical activity and nutrition. We will consider the possible use of the recently developed DNA methylation-based biomarkers of aging called epigenetic clocks in the assessment of physical performance in older individuals. Finally, we will discuss limitations and future directions of this field.
dc.language.isoen
dc.publisherFRONTIERS MEDIA SA
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectPhysiology
dc.subjectaging
dc.subjectmuscle
dc.subjectsarcopenia
dc.subjectepigenetics
dc.subjectDNA methylation
dc.subjectepigenetic clocks
dc.subjectGENE-EXPRESSION PROFILE
dc.subjectALL-CAUSE MORTALITY
dc.subjectSTEM-CELL POOL
dc.subjectEPIGENETIC FACTORS
dc.subjectHANDGRIP STRENGTH
dc.subjectANALYSIS REVEALS
dc.subjectOLDER-ADULTS
dc.subjectEXERCISE
dc.subjectSARCOPENIA
dc.subjectDISEASE
dc.typeReview
dc.date.updated2022-11-29T02:43:44Z
dc.contributor.departmentMEDICINE
dc.description.doi10.3389/fphys.2019.00996
dc.description.sourcetitleFRONTIERS IN PHYSIOLOGY
dc.description.volume10
dc.description.issueJUL
dc.published.statePublished
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