Please use this identifier to cite or link to this item: https://doi.org/10.1093/nutrit/nuaa064
Title: Factors influencing the efficacy of nutritional interventions on muscle mass in older adults: a systematic review and meta-analysis
Authors: Martin-Cantero, Aitana
Reijnierse, Esmee M
Gill, Benjamin MT
Maier, Andrea B 
Keywords: Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
aged
muscle mass
nutrition therapy
sarcopenia
HYDROXY-BETA-METHYLBUTYRATE
PROTEIN SUPPLEMENTATION
PHYSICAL PERFORMANCE
BODY-COMPOSITION
CREATINE SUPPLEMENTATION
DOUBLE-BLIND
VITAMIN-D
LEUCINE SUPPLEMENTATION
AMINO-ACIDS
SARCOPENIA
Issue Date: 1-Mar-2021
Publisher: OXFORD UNIV PRESS INC
Citation: Martin-Cantero, Aitana, Reijnierse, Esmee M, Gill, Benjamin MT, Maier, Andrea B (2021-03-01). Factors influencing the efficacy of nutritional interventions on muscle mass in older adults: a systematic review and meta-analysis. NUTRITION REVIEWS 79 (3) : 315-330. ScholarBank@NUS Repository. https://doi.org/10.1093/nutrit/nuaa064
Abstract: Context: Nutritional interventions stimulate muscle protein synthesis in older adults. To optimize muscle mass preservation and gains, several factors, including type, dose, frequency, timing, duration, and adherence have to be considered. Objective: This systematic review and meta-analysis aimed to summarize these factors influencing the efficacy of nutritional interventions on muscle mass in older adults. Data Sources: A systematic search was performed using the electronic databases MEDLINE, Embase, CINAHL, Cochrane Central Register of Controlled Trials, and SPORTDiscus from inception date to November 22, 2017, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Inclusion criteria included randomized controlled trials, mean or median age ≥65 years, and reporting muscle mass at baseline and postintervention. Exclusion criteria included genetically inherited diseases, anabolic drugs or hormone therapies, neuromuscular electrical stimulation, chronic kidney disease, kidney failure, neuromuscular disorders, and cancer. Data Extraction: Extracted data included study characteristics (ie, population, sample size, age, sex), muscle mass measurements (ie, method, measure, unit), effect of the intervention vs the control group, and nutritional intervention factors (ie, type, composition, dose, duration, frequency, timing, and adherence). Data Analysis: Standardized mean differences and 95%CIs were calculated from baseline to postintervention. A meta-analysis was performed using a random-effects model and grouped by the type of intervention. Conclusions: Twenty-nine studies were included, encompassing 2255 participants (mean age, 78.1 years; SD, 2.22). Amino acids, creatine, β-hydroxy-β-methylbutyrate, and protein with amino acids supplementation significantly improved muscle mass. No effect was found for protein supplementation alone, protein and other components, and polyunsaturated fatty acids. High interstudy variability was observed regarding the dose, duration, and frequency, coupled with inconsistency in reporting timing and adherence. Overall, several nutritional interventions could be effective to improve muscle mass measures in older adults. Because of the substantial variability of the intervention factors among studies, the optimum profile is yet to be established. Systematic Review Registration: PROSPERO registration no. CRD42018111306.
Source Title: NUTRITION REVIEWS
URI: https://scholarbank.nus.edu.sg/handle/10635/234882
ISSN: 0029-6643
1753-4887
DOI: 10.1093/nutrit/nuaa064
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Factors influencing the efficacy of nutritional interventions on muscle mass in older adults a systematic review and meta-an.pdf511.52 kBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

14
checked on Jan 26, 2023

Page view(s)

13
checked on Jan 26, 2023

Download(s)

2
checked on Jan 26, 2023

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.