Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12877-022-03434-4
Title: Differential associations between simple physical performance tests with global and specific cognitive functions in cognitively normal and mild cognitive impairment: a cross-sectional cohort study of Asian community-dwelling older adults
Authors: Ng, Ted Kheng Siang 
Han, Madeline Fu Yun 
Loh, Ping Yeap
Kua, Ee Heok 
Yu, Junhong 
Best, John R
Mahendran, Rathi 
Keywords: Neurocognitive tests
Executive function
Memory
Mild cognitive impairment
Preclinical dementia
Moderating effect
Timed-up-and-go test
Gait speed
Asian
Issue Date: 13-Oct-2022
Publisher: BMC
Citation: Ng, Ted Kheng Siang, Han, Madeline Fu Yun, Loh, Ping Yeap, Kua, Ee Heok, Yu, Junhong, Best, John R, Mahendran, Rathi (2022-10-13). Differential associations between simple physical performance tests with global and specific cognitive functions in cognitively normal and mild cognitive impairment: a cross-sectional cohort study of Asian community-dwelling older adults. BMC GERIATRICS 22 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s12877-022-03434-4
Abstract: Background: Physical performance declines and executive dysfunctions are predictors of dementia. However, their associations are not well understood in Asian older adults without dementia (cognitively normal [CN] and mild cognitive impairment [MCI]), especially in a single study. Objective: Examine the associations between physical performance measures with executive function (EF)-based and non-EF-based neurocognitive tests and whether preclinical dementia cognitive status i.e., CN and MCI, moderated these associations. Methods: We examined cross-sectional cohort of 716 community-dwelling older adults without dementia (CN = 562 and MCI = 154) using multivariable linear regression models. We associated three simple physical performance measures, namely timed-up-and-go (TUG), fast gait speed (FGS), and 30-s chair stand test (30 s-CST), with a comprehensive neurocognitive test battery measuring EF and non-EF cognitive functions. Moderating effects of cognitive status on the associations were examined. In all models, we controlled for pertinent covariates, including age, education, medical and psychiatric status. Results: Upon controlling for covariates, TUG was most strongly and positively associated with multiple EF-based neurocognitive tests, followed by FGS, with 30 s-CST having the weakest associations. For all physical performance measures, no significant associations with non-EF-based neurocognitive tests were detected. Cognitive status significantly moderated the associations between all physical measures and several neurocognitive tests, with stronger associations in the MCI than CN. Conclusion: Compared to FGS and 30 s-CST, TUG had the most robust associations with multiple EF-based cognitive functions. Given their differential associations with global and detailed neurocognitive tests and significant moderating effects of cognitive status, findings highlight a need to carefully consider the choices of simple physical performance tests when using these tests with a heterogenous group of community-dwelling older adults without dementia.
Source Title: BMC GERIATRICS
URI: https://scholarbank.nus.edu.sg/handle/10635/234157
ISSN: 1471-2318
DOI: 10.1186/s12877-022-03434-4
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