Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12877-022-03434-4
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dc.titleDifferential associations between simple physical performance tests with global and specific cognitive functions in cognitively normal and mild cognitive impairment: a cross-sectional cohort study of Asian community-dwelling older adults
dc.contributor.authorNg, Ted Kheng Siang
dc.contributor.authorHan, Madeline Fu Yun
dc.contributor.authorLoh, Ping Yeap
dc.contributor.authorKua, Ee Heok
dc.contributor.authorYu, Junhong
dc.contributor.authorBest, John R
dc.contributor.authorMahendran, Rathi
dc.date.accessioned2022-11-08T04:21:39Z
dc.date.available2022-11-08T04:21:39Z
dc.date.issued2022-10-13
dc.identifier.citationNg, Ted Kheng Siang, Han, Madeline Fu Yun, Loh, Ping Yeap, Kua, Ee Heok, Yu, Junhong, Best, John R, Mahendran, Rathi (2022-10-13). Differential associations between simple physical performance tests with global and specific cognitive functions in cognitively normal and mild cognitive impairment: a cross-sectional cohort study of Asian community-dwelling older adults. BMC GERIATRICS 22 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s12877-022-03434-4
dc.identifier.issn1471-2318
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/234157
dc.description.abstractBackground: Physical performance declines and executive dysfunctions are predictors of dementia. However, their associations are not well understood in Asian older adults without dementia (cognitively normal [CN] and mild cognitive impairment [MCI]), especially in a single study. Objective: Examine the associations between physical performance measures with executive function (EF)-based and non-EF-based neurocognitive tests and whether preclinical dementia cognitive status i.e., CN and MCI, moderated these associations. Methods: We examined cross-sectional cohort of 716 community-dwelling older adults without dementia (CN = 562 and MCI = 154) using multivariable linear regression models. We associated three simple physical performance measures, namely timed-up-and-go (TUG), fast gait speed (FGS), and 30-s chair stand test (30 s-CST), with a comprehensive neurocognitive test battery measuring EF and non-EF cognitive functions. Moderating effects of cognitive status on the associations were examined. In all models, we controlled for pertinent covariates, including age, education, medical and psychiatric status. Results: Upon controlling for covariates, TUG was most strongly and positively associated with multiple EF-based neurocognitive tests, followed by FGS, with 30 s-CST having the weakest associations. For all physical performance measures, no significant associations with non-EF-based neurocognitive tests were detected. Cognitive status significantly moderated the associations between all physical measures and several neurocognitive tests, with stronger associations in the MCI than CN. Conclusion: Compared to FGS and 30 s-CST, TUG had the most robust associations with multiple EF-based cognitive functions. Given their differential associations with global and detailed neurocognitive tests and significant moderating effects of cognitive status, findings highlight a need to carefully consider the choices of simple physical performance tests when using these tests with a heterogenous group of community-dwelling older adults without dementia.
dc.language.isoen
dc.publisherBMC
dc.sourceElements
dc.subjectNeurocognitive tests
dc.subjectExecutive function
dc.subjectMemory
dc.subjectMild cognitive impairment
dc.subjectPreclinical dementia
dc.subjectModerating effect
dc.subjectTimed-up-and-go test
dc.subjectGait speed
dc.subjectAsian
dc.typeArticle
dc.date.updated2022-11-07T08:55:29Z
dc.contributor.departmentDEPT OF PSYCHOLOGICAL MEDICINE
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentPSYCHOLOGICAL MEDICINE
dc.description.doi10.1186/s12877-022-03434-4
dc.description.sourcetitleBMC GERIATRICS
dc.description.volume22
dc.description.issue1
dc.published.statePublished
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