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Title: Exosomes, a New Star for Targeted Delivery
Authors: Chen, Huizhi
Wang, Liyan
Zeng, Xinling
Schwarz, Herbert 
Nanda, Himansu Sekhar
Peng, Xinsheng
Zhou, Yubin
Keywords: drug delivery
exosome engineering
extracellular vesicles
gene delivery
targeted delivery
Issue Date: 8-Oct-2021
Publisher: Frontiers Media S.A.
Citation: Chen, Huizhi, Wang, Liyan, Zeng, Xinling, Schwarz, Herbert, Nanda, Himansu Sekhar, Peng, Xinsheng, Zhou, Yubin (2021-10-08). Exosomes, a New Star for Targeted Delivery. Frontiers in Cell and Developmental Biology 9 : 751079. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Exosomes are cell-secreted nanoparticles (generally with a size of 30–150 nm) bearing numerous biological molecules including nucleic acids, proteins and lipids, which are thought to play important roles in intercellular communication. As carriers, exosomes hold promise as advanced platforms for targeted drug/gene delivery, owing to their unique properties, such as innate stability, low immunogenicity and excellent tissue/cell penetration capacity. However, their practical applications can be limited due to insufficient targeting ability or low efficacy in some cases. In order to overcome these existing challenges, various approaches have been applied to engineer cell-derived exosomes for a higher selectivity and effectiveness. This review presents the state-of-the-art designs and applications of advanced exosome-based systems for targeted cargo delivery. By discussing experts’ opinions, we hope this review will inspire the researchers in this field to develop more practical exosomal delivery systems for clinical applications. © Copyright © 2021 Chen, Wang, Zeng, Schwarz, Nanda, Peng and Zhou.
Source Title: Frontiers in Cell and Developmental Biology
ISSN: 2296-634X
DOI: 10.3389/fcell.2021.751079
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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