Please use this identifier to cite or link to this item: https://doi.org/10.3389/fcell.2021.751079
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dc.titleExosomes, a New Star for Targeted Delivery
dc.contributor.authorChen, Huizhi
dc.contributor.authorWang, Liyan
dc.contributor.authorZeng, Xinling
dc.contributor.authorSchwarz, Herbert
dc.contributor.authorNanda, Himansu Sekhar
dc.contributor.authorPeng, Xinsheng
dc.contributor.authorZhou, Yubin
dc.date.accessioned2022-10-26T09:07:22Z
dc.date.available2022-10-26T09:07:22Z
dc.date.issued2021-10-08
dc.identifier.citationChen, Huizhi, Wang, Liyan, Zeng, Xinling, Schwarz, Herbert, Nanda, Himansu Sekhar, Peng, Xinsheng, Zhou, Yubin (2021-10-08). Exosomes, a New Star for Targeted Delivery. Frontiers in Cell and Developmental Biology 9 : 751079. ScholarBank@NUS Repository. https://doi.org/10.3389/fcell.2021.751079
dc.identifier.issn2296-634X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/233633
dc.description.abstractExosomes are cell-secreted nanoparticles (generally with a size of 30–150 nm) bearing numerous biological molecules including nucleic acids, proteins and lipids, which are thought to play important roles in intercellular communication. As carriers, exosomes hold promise as advanced platforms for targeted drug/gene delivery, owing to their unique properties, such as innate stability, low immunogenicity and excellent tissue/cell penetration capacity. However, their practical applications can be limited due to insufficient targeting ability or low efficacy in some cases. In order to overcome these existing challenges, various approaches have been applied to engineer cell-derived exosomes for a higher selectivity and effectiveness. This review presents the state-of-the-art designs and applications of advanced exosome-based systems for targeted cargo delivery. By discussing experts’ opinions, we hope this review will inspire the researchers in this field to develop more practical exosomal delivery systems for clinical applications. © Copyright © 2021 Chen, Wang, Zeng, Schwarz, Nanda, Peng and Zhou.
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.subjectdrug delivery
dc.subjectexosome engineering
dc.subjectexosomes
dc.subjectextracellular vesicles
dc.subjectgene delivery
dc.subjecttargeted delivery
dc.typeReview
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.3389/fcell.2021.751079
dc.description.sourcetitleFrontiers in Cell and Developmental Biology
dc.description.volume9
dc.description.page751079
dc.published.statePublished
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