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Title: Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain
Authors: D'Gama, Percival P.
Qiu, Tao
Cosacak, Mehmet Ilyas
Rayamajhi, Dheeraj
Konac, Ahsen
Hansen, Jan Niklas
Ringers, Christa
Acuña-Hinrichsen, Francisca
Hui, Subhra P.
Olstad, Emilie W.
Chong, Yan Ling
Lim, Charlton Kang An
Gupta, Astha
Ng, Chee Peng
Nilges, Benedikt S.
Kashikar, Nachiket D.
Wachten, Dagmar
Liebl, David
Kikuchi, Kazu
Kizil, Caghan
Yaksi, Emre
Roy, Sudipto 
Jurisch-Yaksi, Nathalie
Keywords: brain
cerebrospinal fluid
choroid plexus
ependymal cell
multiciliated cells
Issue Date: 1-Oct-2021
Publisher: Elsevier B.V.
Citation: D'Gama, Percival P., Qiu, Tao, Cosacak, Mehmet Ilyas, Rayamajhi, Dheeraj, Konac, Ahsen, Hansen, Jan Niklas, Ringers, Christa, Acuña-Hinrichsen, Francisca, Hui, Subhra P., Olstad, Emilie W., Chong, Yan Ling, Lim, Charlton Kang An, Gupta, Astha, Ng, Chee Peng, Nilges, Benedikt S., Kashikar, Nachiket D., Wachten, Dagmar, Liebl, David, Kikuchi, Kazu, Kizil, Caghan, Yaksi, Emre, Roy, Sudipto, Jurisch-Yaksi, Nathalie (2021-10-01). Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell Reports 37 (1) : 109775. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not fully understood. We have characterized motile ciliated cells within the zebrafish brain ventricles. We show that the ventricles undergo restructuring through development, involving a transition from mono- to multiciliated cells (MCCs) driven by gmnc. MCCs co-exist with monociliated cells and generate directional flow patterns. These ciliated cells have different developmental origins and are genetically heterogenous with respect to expression of the Foxj1 family of ciliary master regulators. Finally, we show that cilia loss from the tela choroida and choroid plexus or global perturbation of multiciliation does not affect overall brain or spine morphogenesis but results in enlarged ventricles. Our findings establish that motile ciliated cells are generated by complementary and sequential transcriptional programs to support ventricular development. © 2021 The Author(s)
Source Title: Cell Reports
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2021.109775
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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