Please use this identifier to cite or link to this item: https://doi.org/10.3389/fimmu.2021.710217
Title: Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
Authors: Lim, Jackwee
Puan, Kia Joo
Wang, Liang Wei
Teng, Karen Wei Weng
Loh, Chiew Yee
Tan, Kim Peng
Carissimo, Guillaume
Chan, Yi-Hao
Poh, Chek Meng
Lee, Cheryl Yi-Pin
Fong, Siew-Wai 
Yeo, Nicholas Kim-Wah
Chee, Rhonda Sin-Ling
Amrun, Siti Naqiah
Chang, Zi Wei
Tay, Matthew Zirui
Torres-Ruesta, Anthony
Leo Fernandez, Norman
How, Wilson
Andiappan, Anand Kumar
Lee, Wendy
Duan, Kaibo
Tan, Seow-Yen
Yan, Gabriel 
Kalimuddin, Shirin 
Lye, David Chien 
Leo, Yee-Sin 
Ong, Sean W. X.
Young, Barnaby E.
Renia, Laurent
Ng, Lisa F. P. 
Lee, Bernett
Rötzschke, Olaf
Keywords: active infection
COVID-19
cytokine profile
immune recovery
immunophenotyping
inflammation
SARS – CoV – 2
severity
Issue Date: 19-Nov-2021
Publisher: Frontiers Media S.A.
Citation: Lim, Jackwee, Puan, Kia Joo, Wang, Liang Wei, Teng, Karen Wei Weng, Loh, Chiew Yee, Tan, Kim Peng, Carissimo, Guillaume, Chan, Yi-Hao, Poh, Chek Meng, Lee, Cheryl Yi-Pin, Fong, Siew-Wai, Yeo, Nicholas Kim-Wah, Chee, Rhonda Sin-Ling, Amrun, Siti Naqiah, Chang, Zi Wei, Tay, Matthew Zirui, Torres-Ruesta, Anthony, Leo Fernandez, Norman, How, Wilson, Andiappan, Anand Kumar, Lee, Wendy, Duan, Kaibo, Tan, Seow-Yen, Yan, Gabriel, Kalimuddin, Shirin, Lye, David Chien, Leo, Yee-Sin, Ong, Sean W. X., Young, Barnaby E., Renia, Laurent, Ng, Lisa F. P., Lee, Bernett, Rötzschke, Olaf (2021-11-19). Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals. Frontiers in Immunology 12 : 710217. ScholarBank@NUS Repository. https://doi.org/10.3389/fimmu.2021.710217
Rights: Attribution 4.0 International
Abstract: Severe SARS-CoV-2 infection can trigger uncontrolled innate and adaptive immune responses, which are commonly associated with lymphopenia and increased neutrophil counts. However, whether the immune abnormalities observed in mild to severely infected patients persist into convalescence remains unclear. Herein, comparisons were drawn between the immune responses of COVID-19 infected and convalescent adults. Strikingly, survivors of severe COVID-19 had decreased proportions of NKT and V?2 T cells, and increased proportions of low-density neutrophils, IgA+/CD86+/CD123+ non-classical monocytes and hyperactivated HLADR+CD38+ CD8+ T cells, and elevated levels of pro-inflammatory cytokines such as hepatocyte growth factor and vascular endothelial growth factor A, long after virus clearance. Our study suggests potential immune correlates of “long COVID-19”, and defines key cells and cytokines that delineate true and quasi-convalescent states. Copyright © 2021 Lim, Puan, Wang, Teng, Loh, Tan, Carissimo, Chan, Poh, Lee, Fong, Yeo, Chee, Amrun, Chang, Tay, Torres-Ruesta, Leo Fernandez, How, Andiappan, Lee, Duan, Tan, Yan, Kalimuddin, Lye, Leo, Ong, Young, Renia, Ng, Lee and Rötzschke.
Source Title: Frontiers in Immunology
URI: https://scholarbank.nus.edu.sg/handle/10635/232781
ISSN: 1664-3224
DOI: 10.3389/fimmu.2021.710217
Rights: Attribution 4.0 International
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