Please use this identifier to cite or link to this item:
https://doi.org/10.3389/fimmu.2021.710217
DC Field | Value | |
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dc.title | Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals | |
dc.contributor.author | Lim, Jackwee | |
dc.contributor.author | Puan, Kia Joo | |
dc.contributor.author | Wang, Liang Wei | |
dc.contributor.author | Teng, Karen Wei Weng | |
dc.contributor.author | Loh, Chiew Yee | |
dc.contributor.author | Tan, Kim Peng | |
dc.contributor.author | Carissimo, Guillaume | |
dc.contributor.author | Chan, Yi-Hao | |
dc.contributor.author | Poh, Chek Meng | |
dc.contributor.author | Lee, Cheryl Yi-Pin | |
dc.contributor.author | Fong, Siew-Wai | |
dc.contributor.author | Yeo, Nicholas Kim-Wah | |
dc.contributor.author | Chee, Rhonda Sin-Ling | |
dc.contributor.author | Amrun, Siti Naqiah | |
dc.contributor.author | Chang, Zi Wei | |
dc.contributor.author | Tay, Matthew Zirui | |
dc.contributor.author | Torres-Ruesta, Anthony | |
dc.contributor.author | Leo Fernandez, Norman | |
dc.contributor.author | How, Wilson | |
dc.contributor.author | Andiappan, Anand Kumar | |
dc.contributor.author | Lee, Wendy | |
dc.contributor.author | Duan, Kaibo | |
dc.contributor.author | Tan, Seow-Yen | |
dc.contributor.author | Yan, Gabriel | |
dc.contributor.author | Kalimuddin, Shirin | |
dc.contributor.author | Lye, David Chien | |
dc.contributor.author | Leo, Yee-Sin | |
dc.contributor.author | Ong, Sean W. X. | |
dc.contributor.author | Young, Barnaby E. | |
dc.contributor.author | Renia, Laurent | |
dc.contributor.author | Ng, Lisa F. P. | |
dc.contributor.author | Lee, Bernett | |
dc.contributor.author | Rötzschke, Olaf | |
dc.date.accessioned | 2022-10-13T01:10:32Z | |
dc.date.available | 2022-10-13T01:10:32Z | |
dc.date.issued | 2021-11-19 | |
dc.identifier.citation | Lim, Jackwee, Puan, Kia Joo, Wang, Liang Wei, Teng, Karen Wei Weng, Loh, Chiew Yee, Tan, Kim Peng, Carissimo, Guillaume, Chan, Yi-Hao, Poh, Chek Meng, Lee, Cheryl Yi-Pin, Fong, Siew-Wai, Yeo, Nicholas Kim-Wah, Chee, Rhonda Sin-Ling, Amrun, Siti Naqiah, Chang, Zi Wei, Tay, Matthew Zirui, Torres-Ruesta, Anthony, Leo Fernandez, Norman, How, Wilson, Andiappan, Anand Kumar, Lee, Wendy, Duan, Kaibo, Tan, Seow-Yen, Yan, Gabriel, Kalimuddin, Shirin, Lye, David Chien, Leo, Yee-Sin, Ong, Sean W. X., Young, Barnaby E., Renia, Laurent, Ng, Lisa F. P., Lee, Bernett, Rötzschke, Olaf (2021-11-19). Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals. Frontiers in Immunology 12 : 710217. ScholarBank@NUS Repository. https://doi.org/10.3389/fimmu.2021.710217 | |
dc.identifier.issn | 1664-3224 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/232781 | |
dc.description.abstract | Severe SARS-CoV-2 infection can trigger uncontrolled innate and adaptive immune responses, which are commonly associated with lymphopenia and increased neutrophil counts. However, whether the immune abnormalities observed in mild to severely infected patients persist into convalescence remains unclear. Herein, comparisons were drawn between the immune responses of COVID-19 infected and convalescent adults. Strikingly, survivors of severe COVID-19 had decreased proportions of NKT and V?2 T cells, and increased proportions of low-density neutrophils, IgA+/CD86+/CD123+ non-classical monocytes and hyperactivated HLADR+CD38+ CD8+ T cells, and elevated levels of pro-inflammatory cytokines such as hepatocyte growth factor and vascular endothelial growth factor A, long after virus clearance. Our study suggests potential immune correlates of “long COVID-19”, and defines key cells and cytokines that delineate true and quasi-convalescent states. Copyright © 2021 Lim, Puan, Wang, Teng, Loh, Tan, Carissimo, Chan, Poh, Lee, Fong, Yeo, Chee, Amrun, Chang, Tay, Torres-Ruesta, Leo Fernandez, How, Andiappan, Lee, Duan, Tan, Yan, Kalimuddin, Lye, Leo, Ong, Young, Renia, Ng, Lee and Rötzschke. | |
dc.publisher | Frontiers Media S.A. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.subject | active infection | |
dc.subject | COVID-19 | |
dc.subject | cytokine profile | |
dc.subject | immune recovery | |
dc.subject | immunophenotyping | |
dc.subject | inflammation | |
dc.subject | SARS – CoV – 2 | |
dc.subject | severity | |
dc.type | Article | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.contributor.department | DEAN'S OFFICE (DENTISTRY) | |
dc.contributor.department | DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.contributor.department | BIOCHEMISTRY | |
dc.description.doi | 10.3389/fimmu.2021.710217 | |
dc.description.sourcetitle | Frontiers in Immunology | |
dc.description.volume | 12 | |
dc.description.page | 710217 | |
Appears in Collections: | Elements Staff Publications |
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