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Title: Factors influencing SARS-CoV-2 transmission and outbreak control measures in densely populated settings
Authors: Pung, Rachael
Lin, Bernard
Maurer-Stroh, Sebastian 
Sirota, Fernanda L.
Mak, Tze Minn
Octavia, Sophie
Pang, Junxiong 
Tan, Iain Beehuat 
Tan, Clive 
Ong, Biauw Chi 
Cook, Alex R. 
Tan, Doreen
Chua, Qin Xuan
Chong, Samuel Zeng Rong
Koh, Han Fang
Yap, Elena
Sia, Priscilla
Tan, Ze Ren
Lee, Fong Sin
Goh, Jun Kang Enan
Suor, Peou Socheata Monica
Ang, Julian Xiao Li
Lee, Vernon J. 
Issue Date: 27-Jul-2021
Publisher: Nature Research
Citation: Pung, Rachael, Lin, Bernard, Maurer-Stroh, Sebastian, Sirota, Fernanda L., Mak, Tze Minn, Octavia, Sophie, Pang, Junxiong, Tan, Iain Beehuat, Tan, Clive, Ong, Biauw Chi, Cook, Alex R., Tan, Doreen, Chua, Qin Xuan, Chong, Samuel Zeng Rong, Koh, Han Fang, Yap, Elena, Sia, Priscilla, Tan, Ze Ren, Lee, Fong Sin, Goh, Jun Kang Enan, Suor, Peou Socheata Monica, Ang, Julian Xiao Li, Lee, Vernon J. (2021-07-27). Factors influencing SARS-CoV-2 transmission and outbreak control measures in densely populated settings. Scientific Reports 11 (1) : 15297. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Starting with a handful of SARS-CoV-2 infections in dormitory residents in late March 2020, rapid transmission in their dense living environments ensued and by October 2020, more than 50,000 acute infections were identified across various dormitories in Singapore. The aim of the study is to identify combination of factors facilitating SARS-CoV-2 transmission and the impact of control measures in a dormitory through extensive epidemiological, serological and phylogenetic investigations, supported by simulation models. Our findings showed that asymptomatic cases and symptomatic cases who did not seek medical attention were major drivers of the outbreak. Furthermore, each resident had about 30 close contacts and each infected resident spread to 4.4 (IQR 3.5–5.3) others at the start of the outbreak. The final attack rate of the current outbreak was 76.2% (IQR 70.6–98.0%) and could be reduced by further 10% under a modified dormitory housing condition. These findings are important when designing living environments in a post COVID-19 future to reduce disease spread and facilitate rapid implementation of outbreak control measures. © 2021, The Author(s).
Source Title: Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-021-94463-3
Rights: Attribution 4.0 International
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