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Title: Non-canonical roles of canonical telomere binding proteins in cancers
Authors: Akincilar, Semih Can
Chan, Claire Hian Tzer
Ng, Qin Feng
Fidan, Kerem
Tergaonkar, Vinay 
Keywords: Cancer
Issue Date: 18-Feb-2021
Publisher: Springer Science and Business Media Deutschland GmbH
Citation: Akincilar, Semih Can, Chan, Claire Hian Tzer, Ng, Qin Feng, Fidan, Kerem, Tergaonkar, Vinay (2021-02-18). Non-canonical roles of canonical telomere binding proteins in cancers. Cellular and Molecular Life Sciences 78 (9) : 4235-4257. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Reactivation of telomerase is a major hallmark observed in 90% of all cancers. Yet paradoxically, enhanced telomerase activity does not correlate with telomere length and cancers often possess short telomeres; suggestive of supplementary non-canonical roles that telomerase might play in the development of cancer. Moreover, studies have shown that aberrant expression of shelterin proteins coupled with their release from shortening telomeres can further promote cancer by mechanisms independent of their telomeric role. While targeting telomerase activity appears to be an attractive therapeutic option, this approach has failed in clinical trials due to undesirable cytotoxic effects on stem cells. To circumvent this concern, an alternative strategy could be to target the molecules involved in the non-canonical functions of telomeric proteins. In this review, we will focus on emerging evidence that has demonstrated the non-canonical roles of telomeric proteins and their impact on tumorigenesis. Furthermore, we aim to address current knowledge gaps in telomeric protein functions and propose future research approaches that can be undertaken to achieve this. © 2021, The Author(s).
Source Title: Cellular and Molecular Life Sciences
ISSN: 1420-682X
DOI: 10.1007/s00018-021-03783-0
Rights: Attribution 4.0 International
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