Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00018-021-03783-0
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dc.titleNon-canonical roles of canonical telomere binding proteins in cancers
dc.contributor.authorAkincilar, Semih Can
dc.contributor.authorChan, Claire Hian Tzer
dc.contributor.authorNg, Qin Feng
dc.contributor.authorFidan, Kerem
dc.contributor.authorTergaonkar, Vinay
dc.date.accessioned2022-10-12T08:16:39Z
dc.date.available2022-10-12T08:16:39Z
dc.date.issued2021-02-18
dc.identifier.citationAkincilar, Semih Can, Chan, Claire Hian Tzer, Ng, Qin Feng, Fidan, Kerem, Tergaonkar, Vinay (2021-02-18). Non-canonical roles of canonical telomere binding proteins in cancers. Cellular and Molecular Life Sciences 78 (9) : 4235-4257. ScholarBank@NUS Repository. https://doi.org/10.1007/s00018-021-03783-0
dc.identifier.issn1420-682X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232613
dc.description.abstractReactivation of telomerase is a major hallmark observed in 90% of all cancers. Yet paradoxically, enhanced telomerase activity does not correlate with telomere length and cancers often possess short telomeres; suggestive of supplementary non-canonical roles that telomerase might play in the development of cancer. Moreover, studies have shown that aberrant expression of shelterin proteins coupled with their release from shortening telomeres can further promote cancer by mechanisms independent of their telomeric role. While targeting telomerase activity appears to be an attractive therapeutic option, this approach has failed in clinical trials due to undesirable cytotoxic effects on stem cells. To circumvent this concern, an alternative strategy could be to target the molecules involved in the non-canonical functions of telomeric proteins. In this review, we will focus on emerging evidence that has demonstrated the non-canonical roles of telomeric proteins and their impact on tumorigenesis. Furthermore, we aim to address current knowledge gaps in telomeric protein functions and propose future research approaches that can be undertaken to achieve this. © 2021, The Author(s).
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.subjectCancer
dc.subjectShelterin
dc.subjectTelomerase
dc.subjectTelomere
dc.subjectTERT
dc.typeReview
dc.contributor.departmentPATHOLOGY
dc.description.doi10.1007/s00018-021-03783-0
dc.description.sourcetitleCellular and Molecular Life Sciences
dc.description.volume78
dc.description.issue9
dc.description.page4235-4257
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