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Title: Tiny mirnas play a big role in the treatment of breast cancer metastasis
Authors: Teo, Andrea York Tiang
Xiang, Xiaoqiang
Le, Minh T. N. 
Wong, Andrea Li-Ann 
Zeng, Qi 
Wang, Lingzhi 
Goh, Boon-Cher 
Keywords: Breast cancer metastasis
Breast cancer therapy
MicroRNA?based therapy
Issue Date: 18-Jan-2021
Publisher: MDPI AG
Citation: Teo, Andrea York Tiang, Xiang, Xiaoqiang, Le, Minh T. N., Wong, Andrea Li-Ann, Zeng, Qi, Wang, Lingzhi, Goh, Boon-Cher (2021-01-18). Tiny mirnas play a big role in the treatment of breast cancer metastasis. Cancers 13 (2) : Jan-24. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Distant organ metastases accounts for the majority of breast cancer deaths. Given the prevalence of breast cancer in women, it is imperative to understand the underlying mechanisms of its metastatic progression and identify potential targets for therapy. Since their discovery in 1993, microRNAs (miRNAs) have emerged as important regulators of tumour progression and metastasis in various cancers, playing either oncogenic or tumour suppressor roles. In the following review, we discuss the roles of miRNAs that potentiate four key areas of breast cancer metastasis— angiogenesis, epithelial?mesenchymal transition, the Warburg effect and the tumour microenvironment. We then evaluate the recent developments in miRNA?based therapies in breast cancer, which have shown substantial promise in controlling tumour progression and metastasis. Yet, certain challenges must be overcome before these strategies can be implemented in clinical trials. © 2021, MDPI AG. All rights reserved.
Source Title: Cancers
ISSN: 2072-6694
DOI: 10.3390/cancers13020337
Rights: Attribution 4.0 International
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