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https://doi.org/10.3390/cancers13020337
Title: | Tiny mirnas play a big role in the treatment of breast cancer metastasis | Authors: | Teo, Andrea York Tiang Xiang, Xiaoqiang Le, Minh T. N. Wong, Andrea Li-Ann Zeng, Qi Wang, Lingzhi Goh, Boon-Cher |
Keywords: | Breast cancer metastasis Breast cancer therapy MicroRNAs MicroRNA?based therapy |
Issue Date: | 18-Jan-2021 | Publisher: | MDPI AG | Citation: | Teo, Andrea York Tiang, Xiang, Xiaoqiang, Le, Minh T. N., Wong, Andrea Li-Ann, Zeng, Qi, Wang, Lingzhi, Goh, Boon-Cher (2021-01-18). Tiny mirnas play a big role in the treatment of breast cancer metastasis. Cancers 13 (2) : Jan-24. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers13020337 | Rights: | Attribution 4.0 International | Abstract: | Distant organ metastases accounts for the majority of breast cancer deaths. Given the prevalence of breast cancer in women, it is imperative to understand the underlying mechanisms of its metastatic progression and identify potential targets for therapy. Since their discovery in 1993, microRNAs (miRNAs) have emerged as important regulators of tumour progression and metastasis in various cancers, playing either oncogenic or tumour suppressor roles. In the following review, we discuss the roles of miRNAs that potentiate four key areas of breast cancer metastasis— angiogenesis, epithelial?mesenchymal transition, the Warburg effect and the tumour microenvironment. We then evaluate the recent developments in miRNA?based therapies in breast cancer, which have shown substantial promise in controlling tumour progression and metastasis. Yet, certain challenges must be overcome before these strategies can be implemented in clinical trials. © 2021, MDPI AG. All rights reserved. | Source Title: | Cancers | URI: | https://scholarbank.nus.edu.sg/handle/10635/232565 | ISSN: | 2072-6694 | DOI: | 10.3390/cancers13020337 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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