Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers13020337
DC FieldValue
dc.titleTiny mirnas play a big role in the treatment of breast cancer metastasis
dc.contributor.authorTeo, Andrea York Tiang
dc.contributor.authorXiang, Xiaoqiang
dc.contributor.authorLe, Minh T. N.
dc.contributor.authorWong, Andrea Li-Ann
dc.contributor.authorZeng, Qi
dc.contributor.authorWang, Lingzhi
dc.contributor.authorGoh, Boon-Cher
dc.date.accessioned2022-10-12T08:13:23Z
dc.date.available2022-10-12T08:13:23Z
dc.date.issued2021-01-18
dc.identifier.citationTeo, Andrea York Tiang, Xiang, Xiaoqiang, Le, Minh T. N., Wong, Andrea Li-Ann, Zeng, Qi, Wang, Lingzhi, Goh, Boon-Cher (2021-01-18). Tiny mirnas play a big role in the treatment of breast cancer metastasis. Cancers 13 (2) : Jan-24. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers13020337
dc.identifier.issn2072-6694
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232565
dc.description.abstractDistant organ metastases accounts for the majority of breast cancer deaths. Given the prevalence of breast cancer in women, it is imperative to understand the underlying mechanisms of its metastatic progression and identify potential targets for therapy. Since their discovery in 1993, microRNAs (miRNAs) have emerged as important regulators of tumour progression and metastasis in various cancers, playing either oncogenic or tumour suppressor roles. In the following review, we discuss the roles of miRNAs that potentiate four key areas of breast cancer metastasis— angiogenesis, epithelial?mesenchymal transition, the Warburg effect and the tumour microenvironment. We then evaluate the recent developments in miRNA?based therapies in breast cancer, which have shown substantial promise in controlling tumour progression and metastasis. Yet, certain challenges must be overcome before these strategies can be implemented in clinical trials. © 2021, MDPI AG. All rights reserved.
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.subjectBreast cancer metastasis
dc.subjectBreast cancer therapy
dc.subjectMicroRNAs
dc.subjectMicroRNA?based therapy
dc.typeReview
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.contributor.departmentDEPT OF PHARMACY
dc.description.doi10.3390/cancers13020337
dc.description.sourcetitleCancers
dc.description.volume13
dc.description.issue2
dc.description.pageJan-24
Appears in Collections:Elements
Staff Publications

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3390_cancers13020337.pdf2.22 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

7
checked on Jan 22, 2023

Page view(s)

20
checked on Jan 26, 2023

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons