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Title: Mitogenomes Reveal Alternative Initiation Codons and Lineage-Specific Gene Order Conservation in Echinoderms
Authors: Quek, Zheng Bin Randolph
Chang, Jia Jin Marc 
Ip, Yin Cheong Aden 
Chan, Yong Kit Samuel 
Huang, Danwei 
Keywords: Asteroidea
mitochondrial gene evolution
mitochondrial gene order
mitochondrial phylogeny
translation table
Issue Date: 7-Oct-2020
Publisher: Oxford University Press
Citation: Quek, Zheng Bin Randolph, Chang, Jia Jin Marc, Ip, Yin Cheong Aden, Chan, Yong Kit Samuel, Huang, Danwei (2020-10-07). Mitogenomes Reveal Alternative Initiation Codons and Lineage-Specific Gene Order Conservation in Echinoderms. Molecular Biology and Evolution 38 (3) : 981-985. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: The mitochondrial genetic code is much more varied than the standard genetic code. The invertebrate mitochondrial code, for instance, comprises six initiation codons, including five alternative start codons. However, only two initiation codons are known in the echinoderm and flatworm mitochondrial code, the canonical ATG and alternative GTG. Here, we analyzed 23 Asteroidea mitogenomes, including ten newly sequenced species and unambiguously identified at least two other start codons, ATT and ATC, both of which also initiate translation of mitochondrial genes in other invertebrates. These findings underscore the diversity of the genetic code and expand upon the suite of initiation codons among echinoderms to avoid erroneous annotations. Our analyses have also uncovered the remarkable conservation of gene order among asteroids, echinoids, and holothuroids, with only an interchange between two gene positions in asteroids over ?500 Ma of echinoderm evolution. © 2020 The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
Source Title: Molecular Biology and Evolution
ISSN: 0737-4038
DOI: 10.1093/molbev/msaa262
Rights: Attribution 4.0 International
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