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Title: Senescence in tissue samples of humans with age-related diseases: A systematic review
Authors: Tuttle, Camilla S. L.
Luesken, Suzanne W. M.
Waaijer, Mariette E. C.
Maier, Andrea B. 
Keywords: Age-related disease
Cellular senescence
Issue Date: 1-Jul-2021
Publisher: Elsevier Ireland Ltd
Citation: Tuttle, Camilla S. L., Luesken, Suzanne W. M., Waaijer, Mariette E. C., Maier, Andrea B. (2021-07-01). Senescence in tissue samples of humans with age-related diseases: A systematic review. Ageing Research Reviews 68 : 101334. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background: Higher numbers of senescent cells have been implicated in age-related disease pathologies. However, whether different diseases have different senescent phenotypes is unknown. Here we provide a systematic overview of the current available evidence of senescent cells in age-related diseases pathologies in humans and the markers currently used to detect senescence levels in humans. Methods: PubMed, Web of Science and EMBASE were systematically searched from inception to the 29th of September 2019, using keywords related to ‘senescence’, ‘age-related diseases’ and ‘biopsies’. Results: In total 12,590 articles were retrieved of which 103 articles were included in this review. The role of senescence in age-related disease has been assessed in 9 different human organ system and 27 different age-related diseases of which heart (27/103) and the respiratory systems (18/103) are the most investigated. Overall, 27 different markers of senescence have been used to determine cellular senescence and the cell cycle regulator p16ink4a is most often used (23/27 age-related pathologies). Conclusion: This review demonstrates that a higher expression of senescence markers are observed within disease pathologies. However, not all markers to detect senescence have been assessed in all tissue types. © 2021 The Author(s)
Source Title: Ageing Research Reviews
ISSN: 1568-1637
DOI: 10.1016/j.arr.2021.101334
Rights: Attribution 4.0 International
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