Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.arr.2021.101334
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dc.titleSenescence in tissue samples of humans with age-related diseases: A systematic review
dc.contributor.authorTuttle, Camilla S. L.
dc.contributor.authorLuesken, Suzanne W. M.
dc.contributor.authorWaaijer, Mariette E. C.
dc.contributor.authorMaier, Andrea B.
dc.date.accessioned2022-10-11T08:08:51Z
dc.date.available2022-10-11T08:08:51Z
dc.date.issued2021-07-01
dc.identifier.citationTuttle, Camilla S. L., Luesken, Suzanne W. M., Waaijer, Mariette E. C., Maier, Andrea B. (2021-07-01). Senescence in tissue samples of humans with age-related diseases: A systematic review. Ageing Research Reviews 68 : 101334. ScholarBank@NUS Repository. https://doi.org/10.1016/j.arr.2021.101334
dc.identifier.issn1568-1637
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/232225
dc.description.abstractBackground: Higher numbers of senescent cells have been implicated in age-related disease pathologies. However, whether different diseases have different senescent phenotypes is unknown. Here we provide a systematic overview of the current available evidence of senescent cells in age-related diseases pathologies in humans and the markers currently used to detect senescence levels in humans. Methods: PubMed, Web of Science and EMBASE were systematically searched from inception to the 29th of September 2019, using keywords related to ‘senescence’, ‘age-related diseases’ and ‘biopsies’. Results: In total 12,590 articles were retrieved of which 103 articles were included in this review. The role of senescence in age-related disease has been assessed in 9 different human organ system and 27 different age-related diseases of which heart (27/103) and the respiratory systems (18/103) are the most investigated. Overall, 27 different markers of senescence have been used to determine cellular senescence and the cell cycle regulator p16ink4a is most often used (23/27 age-related pathologies). Conclusion: This review demonstrates that a higher expression of senescence markers are observed within disease pathologies. However, not all markers to detect senescence have been assessed in all tissue types. © 2021 The Author(s)
dc.publisherElsevier Ireland Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2021
dc.subjectAge-related disease
dc.subjectAgeing
dc.subjectCellular senescence
dc.subjectHumans
dc.subjectPathology
dc.typeReview
dc.contributor.departmentDEPT OF MEDICINE
dc.description.doi10.1016/j.arr.2021.101334
dc.description.sourcetitleAgeing Research Reviews
dc.description.volume68
dc.description.page101334
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