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Title: Wolfberry (Lycium barbarum) consumption with a healthy dietary pattern lowers oxidative stress in middle-aged and older adults: A randomized controlled trial
Authors: Toh, Darel Wee Kiat
Lee, Wan Yee
Zhou, Hanzhang
Sutanto, Clarinda Nataria 
Lee, Delia Pei Shan
Tan, Denise
Kim, Jung Eun 
Keywords: Antioxidant
Body composition
Lycium barbarum
Oxidative stress
Plasma carotenoids
Randomized controlled trial
Skin carotenoids
Issue Date: 7-Apr-2021
Publisher: MDPI
Citation: Toh, Darel Wee Kiat, Lee, Wan Yee, Zhou, Hanzhang, Sutanto, Clarinda Nataria, Lee, Delia Pei Shan, Tan, Denise, Kim, Jung Eun (2021-04-07). Wolfberry (Lycium barbarum) consumption with a healthy dietary pattern lowers oxidative stress in middle-aged and older adults: A randomized controlled trial. Antioxidants 10 (4) : 567. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Incorporating zeaxanthin-rich wolfberry (Lycium barbarum) into a healthy dietary pattern may augment its antioxidant potential. The present 16-week, parallel design randomized controlled trial aimed to investigate the impact of adhering to a healthy dietary pattern, either with or without whole dried wolfberry (15 g/d) on oxidative stress status (plasma malondialdehyde and 8-iso-prostaglandin F2α) in middle-aged and older adults. Changes to carotenoids status (plasma and skin carotenoids) and body composition were further evaluated to explore potential mechanisms which underlie the antioxidant properties of wolfberry. Plasma 8-iso-prostaglandin F2α, plasma zeaxanthin and skin carotenoids status were significantly raised in the wolfberry consuming group (n = 22; p < 0.05) compared to the control group which showed no changes (n = 18). Likewise in the wolfberry group only, inverse association was observed between the change values of plasma zeaxanthin and plasma 8-iso-prostaglandin F2α (−0.21 (−0.43, 0.00) ng/µmol, regression coefficient (95% CI); p = 0.05). Wolfberry consumption with a healthy dietary pattern may serve as a dietary strategy to attenuate lipid peroxidation among middle-aged and older adults who are at a heightened risk of oxidative stress induced age-related disorders. The antioxidant properties of wolfberry may be attributed to its rich zeaxanthin content. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Antioxidants
ISSN: 2076-3921
DOI: 10.3390/antiox10040567
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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