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dc.titleWolfberry (Lycium barbarum) consumption with a healthy dietary pattern lowers oxidative stress in middle-aged and older adults: A randomized controlled trial
dc.contributor.authorToh, Darel Wee Kiat
dc.contributor.authorLee, Wan Yee
dc.contributor.authorZhou, Hanzhang
dc.contributor.authorSutanto, Clarinda Nataria
dc.contributor.authorLee, Delia Pei Shan
dc.contributor.authorTan, Denise
dc.contributor.authorKim, Jung Eun
dc.identifier.citationToh, Darel Wee Kiat, Lee, Wan Yee, Zhou, Hanzhang, Sutanto, Clarinda Nataria, Lee, Delia Pei Shan, Tan, Denise, Kim, Jung Eun (2021-04-07). Wolfberry (Lycium barbarum) consumption with a healthy dietary pattern lowers oxidative stress in middle-aged and older adults: A randomized controlled trial. Antioxidants 10 (4) : 567. ScholarBank@NUS Repository.
dc.description.abstractIncorporating zeaxanthin-rich wolfberry (Lycium barbarum) into a healthy dietary pattern may augment its antioxidant potential. The present 16-week, parallel design randomized controlled trial aimed to investigate the impact of adhering to a healthy dietary pattern, either with or without whole dried wolfberry (15 g/d) on oxidative stress status (plasma malondialdehyde and 8-iso-prostaglandin F2α) in middle-aged and older adults. Changes to carotenoids status (plasma and skin carotenoids) and body composition were further evaluated to explore potential mechanisms which underlie the antioxidant properties of wolfberry. Plasma 8-iso-prostaglandin F2α, plasma zeaxanthin and skin carotenoids status were significantly raised in the wolfberry consuming group (n = 22; p < 0.05) compared to the control group which showed no changes (n = 18). Likewise in the wolfberry group only, inverse association was observed between the change values of plasma zeaxanthin and plasma 8-iso-prostaglandin F2α (−0.21 (−0.43, 0.00) ng/µmol, regression coefficient (95% CI); p = 0.05). Wolfberry consumption with a healthy dietary pattern may serve as a dietary strategy to attenuate lipid peroxidation among middle-aged and older adults who are at a heightened risk of oxidative stress induced age-related disorders. The antioxidant properties of wolfberry may be attributed to its rich zeaxanthin content. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.rightsAttribution 4.0 International
dc.sourceScopus OA2021
dc.subjectBody composition
dc.subjectLycium barbarum
dc.subjectOxidative stress
dc.subjectPlasma carotenoids
dc.subjectRandomized controlled trial
dc.subjectSkin carotenoids
dc.contributor.departmentFOOD SCIENCE & TECHNOLOGY
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